ANAPC10

ANAPC10
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1JHJ, 4UI9, 5A31, 5G05, 5G04
Identifiers
Aliases	ANAPC10, APC10, DOC1, anaphase promoting complex subunit 10
External IDs	OMIM: 613745; MGI: 1916249; HomoloGene: 32238; GeneCards: ANAPC10; OMA:ANAPC10 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	145,098,541 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	80,505,688 bp
RNA expression pattern
	Top expressed in
	oocyte; ; Achilles tendon; ; secondary oocyte; ; gonad; ; ventricular zone; ; ganglionic eminence; ; tibial arteries; ; right testis; ; left testis; ; gastrocnemius muscle;
	Top expressed in
	hand; ; medial ganglionic eminence; ; morula; ; blastocyst; ; seminiferous tubule; ; superior cervical ganglion; ; abdominal wall; ; vas deferens; ; atrioventricular valve; ; mandibular prominence;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ubiquitin protein ligase activity;
Cellular component	cytoplasm; nucleoplasm; cytosol; anaphase-promoting complex;
Biological process	cell cycle; protein ubiquitination; protein K11-linked ubiquitination; cell division; anaphase-promoting complex-dependent catabolic process; positive regulation of ubiquitin protein ligase activity; regulation of mitotic cell cycle phase transition; ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	10393
	68999
	ENSG00000164162
	ENSMUSG00000036977
	Q9UM13
	Q8K2H6
NM_001256706; NM_001256707; NM_001256708; NM_001256709; NM_001256710;
	NM_001256711; NM_001256712; NM_014885; NM_001318367
	NM_026904; NM_001357234; NM_001357235; NM_001357236; NM_001357237
NP_001243635; NP_001243636; NP_001243637; NP_001243638; NP_001243639;
	NP_001243640; NP_001243641; NP_001305296; NP_055700
	NP_081180; NP_001344163; NP_001344164; NP_001344165; NP_001344166
	Wikidata
View/Edit Human	View/Edit Mouse

Anaphase-promoting complex subunit 10 is an enzyme that in humans is encoded by the ANAPC10 gene.^[5]^[6]^[7]

Template:PBB Summary

Interactions

ANAPC10 has been shown to interact with CDC27,^[8]^[9] Mothers against decapentaplegic homolog 3^[10] and Mothers against decapentaplegic homolog 2.^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164162 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036977 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Grossberger R, Gieffers C, Zachariae W, Podtelejnikov AV, Schleiffer A, Nasmyth K, Mann M, Peters JM (Jun 1999). "Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex". J Biol Chem. 274 (20): 14500–7. doi:10.1074/jbc.274.20.14500. PMID 10318877.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
^ "Entrez Gene: ANAPC10 anaphase promoting complex subunit 10".
^ Vodermaier, Hartmut C; Gieffers, Christian; Maurer-Stroh, Sebastian; Eisenhaber, Frank; Peters, Jan-Michael (Sep 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17). England: 1459–68. doi:10.1016/S0960-9822(03)00581-5. ISSN 0960-9822. PMID 12956947. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help)
^ Gmachl, M; Gieffers C; Podtelejnikov A V; Mann M; Peters J M (Aug 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proc. Natl. Acad. Sci. U.S.A. 97 (16). UNITED STATES: 8973–8. Bibcode:2000PNAS...97.8973G. doi:10.1073/pnas.97.16.8973. ISSN 0027-8424. PMC 16806. PMID 10922056. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ ^a ^b Nourry, Claire; Maksumova Lola; Pang Mona; Liu Xiaohong; Wang Tongwen (May 2004). "Direct interaction between Smad3, APC10, CDH1 and HEF1 in proteasomal degradation of HEF1". BMC Cell Biol. 5. England: 20. doi:10.1186/1471-2121-5-20. PMC 420458. PMID 15144564. {{cite journal}}: Cite has empty unknown parameters: |laysummary=, |laydate=, and |laysource= (help)CS1 maint: unflagged free DOI (link)

External links

ANAPC10 human gene location in the UCSC Genome Browser.
ANAPC10 human gene details in the UCSC Genome Browser.

Template:PBB Controls

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164162 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036977 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10318877-5] Grossberger R, Gieffers C, Zachariae W, Podtelejnikov AV, Schleiffer A, Nasmyth K, Mann M, Peters JM (Jun 1999). "Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex". J Biol Chem. 274 (20): 14500–7. doi:10.1074/jbc.274.20.14500. PMID 10318877.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[pmid11230166-6] Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.

[entrez-7] "Entrez Gene: ANAPC10 anaphase promoting complex subunit 10".

[pmid12956947-8] Vodermaier, Hartmut C; Gieffers, Christian; Maurer-Stroh, Sebastian; Eisenhaber, Frank; Peters, Jan-Michael (Sep 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17). England: 1459–68. doi:10.1016/S0960-9822(03)00581-5. ISSN 0960-9822. PMID 12956947. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help)

[pmid10922056-9] Gmachl, M; Gieffers C; Podtelejnikov A V; Mann M; Peters J M (Aug 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proc. Natl. Acad. Sci. U.S.A. 97 (16). UNITED STATES: 8973–8. Bibcode:2000PNAS...97.8973G. doi:10.1073/pnas.97.16.8973. ISSN 0027-8424. PMC 16806. PMID 10922056. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

[pmid15144564-10] Nourry, Claire; Maksumova Lola; Pang Mona; Liu Xiaohong; Wang Tongwen (May 2004). "Direct interaction between Smad3, APC10, CDH1 and HEF1 in proteasomal degradation of HEF1". BMC Cell Biol. 5. England: 20. doi:10.1186/1471-2121-5-20. PMC 420458. PMID 15144564. {{cite journal}}: Cite has empty unknown parameters: |laysummary=, |laydate=, and |laysource= (help)CS1 maint: unflagged free DOI (link)

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Interactions

References

Further reading

External links