ANKRD15

KANK1
Identifiers
Aliases	KANK1, ANKRD15, CPSQ2, KANK, KN motif and ankyrin repeat domains 1
External IDs	OMIM: 607704; MGI: 2147707; HomoloGene: 17706; GeneCards: KANK1; OMA:KANK1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	746,105 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	25,411,860 bp
RNA expression pattern
	Top expressed in
	cartilage tissue; ; Descending thoracic aorta; ; ascending aorta; ; cardiac muscle tissue of right atrium; ; popliteal artery; ; tibial arteries; ; gingival epithelium; ; myocardium of left ventricle; ; saphenous vein; ; right auricle;
	Top expressed in
	fourth ventricle; ; choroid plexus of fourth ventricle; ; hand; ; interventricular septum; ; Dermatocranium; ; membranous bone; ; basilar part of occipital bone; ; ascending aorta; ; aortic valve; ; inner renal medulla;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	beta-catenin binding; protein binding;
Cellular component	cytoplasm; cell projection; membrane; plasma membrane; ruffle membrane; nucleus;
Biological process	negative regulation of neuron projection development; regulation of transcription, DNA-templated; negative regulation of actin filament polymerization; negative regulation of ruffle assembly; negative regulation of Rho protein signal transduction; positive regulation of wound healing; transcription, DNA-templated; positive regulation of Wnt signaling pathway; negative regulation of insulin receptor signaling pathway; negative regulation of cell migration; negative regulation of lamellipodium morphogenesis; negative regulation of substrate adhesion-dependent cell spreading; regulation of establishment of cell polarity; positive regulation of canonical Wnt signaling pathway; regulation of Rho protein signal transduction; glomerular visceral epithelial cell migration; cell population proliferation; actin cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologs
	23189
	107351
	ENSG00000107104
	ENSMUSG00000032702
	Q14678
	n/a
NM_001256876; NM_001256877; NM_015158; NM_153186; NM_001354331;
	NM_001354332; NM_001354333; NM_001354334; NM_001354335; NM_001354336; NM_001354337; NM_001354338; NM_001354339; NM_001354340; NM_001354341; NM_001354342; NM_001354343; NM_001354344
	NM_181404; NM_001348180
NP_001243805; NP_001243806; NP_055973; NP_694856; NP_001341260;
	NP_001341261; NP_001341262; NP_001341263; NP_001341264; NP_001341265; NP_001341266; NP_001341267; NP_001341268; NP_001341269; NP_001341270; NP_001341271; NP_001341272; NP_001341273
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

KN motif and ankyrin repeat domain-containing protein 1 is a protein that in humans is encoded by the KANK1 gene.^[5]^[6]^[7]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000107104 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032702 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sarkar S, Roy BC, Hatano N, Aoyagi T, Gohji K, Kiyama R (Sep 2002). "A novel ankyrin repeat-containing gene (Kank) located at 9p24 is a growth suppressor of renal cell carcinoma". J Biol Chem. 277 (39): 36585–91. doi:10.1074/jbc.M204244200. PMID 12133830.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Zhu Y, Kakinuma N, Wang Y, Kiyama R (Jan 2008). "Kank proteins: a new family of ankyrin-repeat domain-containing proteins". Biochim Biophys Acta. 1780 (2): 128–33. doi:10.1016/j.bbagen.2007.09.017. PMID 17996375.
^ "Entrez Gene: ANKRD15 ankyrin repeat domain 15".

References

Further reading