AOC2

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AOC2
Identifiers
AliasesAOC2, DAO2, RAO, amine oxidase, copper containing 2, SSAO, amine oxidase copper containing 2
External IDsMGI: 2668431 HomoloGene: 56457 GeneCards: AOC2
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for AOC2
Genomic location for AOC2
Band17q21.31Start42,844,580 bp[1]
End42,850,707 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_009590
NM_001158

NM_178932

RefSeq (protein)

NP_001149
NP_033720

NP_849263

Location (UCSC)Chr 17: 42.84 – 42.85 MbChr 11: 101.33 – 101.33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Amine oxidase, copper containing 2 is a protein that in humans is encoded by the AOC2 gene.[5]

Function[edit]

Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. This gene shows high sequence similarity to copper amine oxidases from various species ranging from bacteria to mammals. The protein contains several conserved motifs including the active site of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine. This gene may be a candidate gene for hereditary ocular diseases. Alternate splicing results in multiple transcript variants.

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000131480 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000078651 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ "Entrez Gene: Amine oxidase, copper containing 2". Retrieved 2015-12-31.

External links[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.