This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. Rare read-through transcripts, containing exons from the PRR5 gene which is located immediately upstream, led to the original description of this gene as encoding a RHOGAP protein containing the proline-rich domains characteristic of PRR5 proteins. Alternatively spliced variants encoding different isoforms have been described.
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Lua BL, Low BC (2005). "Filling the GAPs in cell dynamics control: BPGAP1 promotes cortactin translocation to the cell periphery for enhanced cell migration". Biochem. Soc. Trans. 32 (Pt 6): 1110–2. doi:10.1042/BST0321110. PMID15506981.
Lua BL, Low BC (2005). "Activation of EGF receptor endocytosis and ERK1/2 signaling by BPGAP1 requires direct interaction with EEN/endophilin II and a functional RhoGAP domain". J. Cell Sci. 118 (Pt 12): 2707–2721. doi:10.1242/jcs.02383. PMID15944398.