ARHGAP8

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ARHGAP8
Identifiers
Aliases ARHGAP8, BPGAP1, PP610, Rho GTPase activating protein 8
External IDs MGI: 1920417 HomoloGene: 23645 GeneCards: ARHGAP8
Gene location (Human)
Chromosome 22 (human)
Chr. Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for ARHGAP8
Genomic location for ARHGAP8
Band 22q13.31 Start 44,752,558 bp[1]
End 44,862,788 bp[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_181335
NM_001017526
NM_001198726

NM_001164627
NM_001164628
NM_001205334
NM_028455

RefSeq (protein)

NP_001017526
NP_001185655
NP_851852

NP_001158099
NP_001158100
NP_001192263
NP_082731

Location (UCSC) Chr 22: 44.75 – 44.86 Mb Chr 22: 84.72 – 84.77 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Rho GTPase-activating protein 8 is an protein that in humans is encoded by the ARHGAP8 gene.[5][6]

Function[edit]

This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. Rare read-through transcripts, containing exons from the PRR5 gene which is located immediately upstream, led to the original description of this gene as encoding a RHOGAP protein containing the proline-rich domains characteristic of PRR5 proteins. Alternatively spliced variants encoding different isoforms have been described.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000241484 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000078954 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–495. doi:10.1038/990031. PMID 10591208. 
  6. ^ a b "Entrez Gene: ARHGAP8 Rho GTPase activating protein 8". 

External links[edit]

Further reading[edit]