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Protein ARL3 PDB 1fzq.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases ARL3, ARFL3, ADP ribosylation factor like GTPase 3
External IDs MGI: 1929699 HomoloGene: 48276 GeneCards: ARL3
RNA expression pattern
PBB GE ARL3 213433 at fs.png

PBB GE ARL3 202641 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 10: 102.67 – 102.71 Mb Chr 19: 46.53 – 46.57 Mb
PubMed search [1] [2]
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ADP-ribosylation factor-like protein 3 is a protein that in humans is encoded by the ARL3 gene.[3][4][5]


ADP-ribosylation factor-like 3 is a member of the ADP-ribosylation factor family of GTP-binding proteins. ARL3 binds guanine nucleotides but lacks ADP-ribosylation factor activity.[5]


ARL3 has been shown to interact with Protein unc-119 homolog.[6][7]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Cavenagh MM, Breiner M, Schurmann A, Rosenwald AG, Terui T, Zhang C, Randazzo PA, Adams M, Joost HG, Kahn RA (August 1994). "ADP-ribosylation factor (ARF)-like 3, a new member of the ARF family of GTP-binding proteins cloned from human and rat tissues". J. Biol. Chem. 269 (29): 18937–42. PMID 8034651. 
  4. ^ Kim HS (March 1999). "Assignment of the human ADP-ribosylation factor-like 3 (ARL3) gene to chromosome 10 band q23.3 by radiation hybrid mapping". Cytogenet. Cell Genet. 83 (3-4): 246. doi:10.1159/000015194. PMID 10072593.  Check date values in: |year= / |date= mismatch (help)
  5. ^ a b "Entrez Gene: ARL3 ADP-ribosylation factor-like 3". 
  6. ^ Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070. 
  7. ^ Van Valkenburgh H, Shern JF, Sharer JD, Zhu X, Kahn RA (June 2001). "ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins". J. Biol. Chem. 276 (25): 22826–37. doi:10.1074/jbc.M102359200. PMID 11303027. 

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