Autophagy protein 5

ATG5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4GDK, 4GDL, 4NAW, 4TQ0, 4TQ1, 5D7G
Identifiers
Aliases	ATG5, APG5, APG5-LIKE, APG5L, ASP, hAPG5, autophagy related 5, SCAR25
External IDs	OMIM: 604261; MGI: 1277186; HomoloGene: 3566; GeneCards: ATG5; OMA:ATG5 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	106,325,791 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	44,240,287 bp
RNA expression pattern
	Top expressed in
	gonad; ; mucosa of colon; ; mucosa of sigmoid colon; ; Achilles tendon; ; jejunal mucosa; ; endothelial cell; ; oocyte; ; rectum; ; islet of Langerhans; ; testicle;
	Top expressed in
	primary oocyte; ; secondary oocyte; ; zygote; ; facial motor nucleus; ; lacrimal gland; ; epithelium of stomach; ; left lobe of liver; ; Rostral migratory stream; ; seminal vesicula; ; transitional epithelium of urinary bladder;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	Atg8 ligase activity; protein binding;
Cellular component	cytoplasm; phagophore assembly site membrane; cytosol; phagocytic vesicle membrane; membrane; Atg12-Atg5-Atg16 complex; autophagosome; axoneme; mitochondria associated membranes;
Biological process	immune system process; negative regulation of cell death; C-terminal protein lipidation; autophagy of nucleus; cellular response to nitrogen starvation; apoptotic process; autophagosome assembly; autophagy of mitochondrion; blood vessel remodeling; cellular response to starvation; response to fungus; macroautophagy; cellular homeostasis; antigen processing and presentation of endogenous antigen; negative regulation of protein ubiquitination; aggrephagy; negative stranded viral RNA replication; vasodilation; negative regulation of apoptotic process; post-translational protein modification; negative thymic T cell selection; otolith development; negative regulation of phagocytosis; regulation of release of sequestered calcium ion into cytosol; ventricular cardiac muscle cell development; heart contraction; protein lipidation involved in autophagosome assembly; positive regulation of mucus secretion; cellular response to nitrosative stress; regulation of cilium assembly; regulation of reactive oxygen species metabolic process; negative regulation of reactive oxygen species metabolic process; negative regulation of histone H4-K16 acetylation; autophagy;
	Sources:Amigo / QuickGO
Orthologs
	9474
	11793
	ENSG00000057663
	ENSMUSG00000038160
	Q9H1Y0
	Q99J83
	NM_001286106; NM_001286107; NM_001286108; NM_001286111; NM_004849
	NM_053069; NM_001314013; NM_001358596
	NP_001273035; NP_001273036; NP_001273037; NP_001273040; NP_004840
	NP_001300942; NP_444299; NP_001345525
	Wikidata
View/Edit Human	View/Edit Mouse

Autophagy protein 5 is a protein that in humans is encoded by the ATG5 gene.^[5]^[6]^[7]^[8] It is an E3 ubiquitin ligase which is necessary for autophagy due to its role in autophagosome elongation. It is activated by ATG7 and forms a complex with ATG12 and ATG16L1. This complex is necessary for LC3-1 conjugation to PE to form LC3-II.

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000057663 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038160 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hammond EM, Brunet CL, Johnson GD, Parkhill J, Milner AE, Brady G, Gregory CD, Grand RJ (May 1998). "Homology between a human apoptosis specific protein and the product of APG5, a gene involved in autophagy in yeast". FEBS Lett. 20 (3): 391–5. doi:10.1016/S0014-5793(98)00266-X. PMID 9563500.
^ Baumann P, Cech TR (May 2001). "Pot1, the putative telomere end-binding protein in fission yeast and humans". Science. 292 (5519): 1171–5. doi:10.1126/science.1060036. PMID 11349150.
^ Pyo JO, Jang MH, Kwon YK, Lee HJ, Jun JI, Woo HN, Cho DH, Choi B, Lee H, Kim JH, Mizushima N, Oshumi Y, Jung YK (May 2005). "Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death". J Biol Chem. 280 (21): 20722–9. doi:10.1074/jbc.M413934200. PMID 15778222.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ "Entrez Gene: ATG5 ATG5 autophagy related 5 homolog (S. cerevisiae)".

References

Further reading