A representative 6-sugar fragment of acemannan
CompTox Dashboard (EPA)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Chemical structure and properties
Acemannan has been demonstrated to induce macrophages to secrete interferon (IFN), tumor necrosis factor-α (TNF-α) and interleukins (IL-1); therefore, it might help to prevent or abrogate viral infection. These three cytokines are known to cause inflammation, and interferon is released in response to viral infections. In vitro studies have shown acemannan to inhibit HIV replication; however, in vivo studies have been inconclusive.
Acemannan is currently being used for treatment and clinical management of fibrosarcoma in dogs and cats. Administration of acemannan has been shown to increase tumor necrosis and prolonged host survival; the animals have demonstrated lymphoid infiltration and encapsulation.
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- "Archived copy". Archived from the original on 2008-07-03. Retrieved 2009-04-02.CS1 maint: archived copy as title (link)