Jump to content

Acromegaly: Difference between revisions

From Wikipedia, the free encyclopedia
Content deleted Content added
Line 39: Line 39:
==Causes==
==Causes==
===Pituitary adenoma===
===Pituitary adenoma===
In over 90 percent of acromegaly patients, the overproduction of growth hormones is caused by a [[benign tumor]] of the pituitary gland, called an [[pituitary adenoma|adenoma]]. These tumors produce excess growth hormones and, as they expand, compress surrounding brain tissues, such as the [[optic nerve]]s. This expansion causes the headaches and visual disturbances that often accompany acromegaly. In addition, compression of the surrounding normal pituitary tissue can alter production of other [[hormones]], leading to changes in [[menstruation]] and breast discharge in women and [[impotence]] in men because of reduced [[testosterone]] production.
In over 90 percent of acromegaly patients, the overproduction of growth hormones is caused by a [[benign tumor]] of the pituitary gland, called an [[pituitary adenoma|adenoma]]. These tumors produce excess growth hormones and, as they expand, compress surrounding brain tissues, such as the [[optic nerve]]s. This expansion causes the headaches and visual disturbances that often accompany ugly nasty old women to rape you. In addition, compression of the surrounding normal pituitary tissue can alter production of other [[hormones]], leading to changes in [[menstruation]] and breast discharge in women and [[impotence]] in men because of reduced [[testosterone]] production.


There is a marked variation in rates of GH production and the aggressiveness of the tumor. Some adenomas grow slowly and symptoms of growth hormone excess are often not noticed for many years. Other adenomas grow rapidly and invade surrounding brain areas or the [[Paranasal sinuses|sinuses]], which are located near the pituitary. In general, younger patients tend to have more aggressive tumors.
There is a marked variation in rates of GH production and the aggressiveness of the tumor. Some adenomas grow slowly and symptoms of growth hormone excess are often not noticed for many years. Other adenomas grow rapidly and invade surrounding brain areas or the [[Paranasal sinuses|sinuses]], which are located near the pituitary. In general, younger patients tend to have more aggressive tumors.

Revision as of 20:15, 15 May 2013

Acromegaly
SpecialtyEndocrinology Edit this on Wikidata

Acromegaly (/[invalid input: 'icon']ˌækr[invalid input: 'ɵ']ˈmɛɡəli/; from Greek άκρος akros "extreme" or "extremities" and μεγάλος megalos "large") is a syndrome that results when the anterior pituitary gland produces excess growth hormone (GH) after epiphyseal plate closure at puberty. A number of disorders may increase the pituitary's GH output, although most commonly it involves a GH-producing tumor called pituitary adenoma, derived from a distinct type of cell (somatotrophs).

Acromegaly most commonly affects adults in middle age,[1] and can result in severe disfigurement, complicating conditions, and premature death if unchecked. Because of its pathogenesis and slow progression, the disease is hard to diagnose in the early stages and is frequently missed for years until changes in external features, especially of the face, become noticeable.

Acromegaly is often associated with gigantism.

Signs and symptoms

Features that result from high level of GH or expanding tumor include:

  • Soft tissue swelling visibly resulting in enlargement of the hands, feet, nose, lips and ears, and a general thickening of the skin.
  • Soft tissue swelling of internal organs, notably the heart with attendant weakening of its muscularity, and the kidneys, also the vocal cords resulting in a characteristic thick, deep voice and slowing of speech
  • Generalized expansion of the skull at the fontanelle
  • Pronounced brow protrusion, often with ocular distension
  • Pronounced lower jaw protrusion with attendant macroglossia (enlargement of the tongue) and teeth gapping
  • Hypertrichosis, hyperpigmentation, and hyperhidrosis may occur in these patients.[2]: 499 
  • Acrochordon (skin tags)
  • Carpal tunnel syndrome

Causes

Pituitary adenoma

In over 90 percent of acromegaly patients, the overproduction of growth hormones is caused by a benign tumor of the pituitary gland, called an adenoma. These tumors produce excess growth hormones and, as they expand, compress surrounding brain tissues, such as the optic nerves. This expansion causes the headaches and visual disturbances that often accompany ugly nasty old women to rape you. In addition, compression of the surrounding normal pituitary tissue can alter production of other hormones, leading to changes in menstruation and breast discharge in women and impotence in men because of reduced testosterone production.

There is a marked variation in rates of GH production and the aggressiveness of the tumor. Some adenomas grow slowly and symptoms of growth hormone excess are often not noticed for many years. Other adenomas grow rapidly and invade surrounding brain areas or the sinuses, which are located near the pituitary. In general, younger patients tend to have more aggressive tumors.

Most pituitary tumors arise spontaneously and are not genetically inherited. Many pituitary tumors arise from a genetic alteration in a single pituitary cell which leads to increased cell division and tumor formation. This genetic change, or mutation, is not present at birth, but is acquired during life. The mutation occurs in a gene that regulates the transmission of chemical signals within pituitary cells; it permanently switches on the signal that tells the cell to divide and secrete growth hormones. The events within the cell that cause disordered pituitary cell growth and growth hormone oversecretion currently are the subject of intensive research.

Other tumors

In a few patients, acromegaly is caused not by pituitary tumors but by tumors of the pancreas, lungs, and adrenal glands. These tumors also lead to an excess of GH, either because they produce GH themselves or, more frequently, because they produce GHRH (Growth Hormone Releasing Hormone), the hormone that stimulates the pituitary to make GH. In these patients, the excess GHRH can be measured in the blood and establishes that the cause of the acromegaly is not due to a pituitary defect. When these non-pituitary tumors are surgically removed, GH levels fall and the symptoms of acromegaly improve.

In patients with GHRH-producing, non-pituitary tumors, the pituitary still may be enlarged and may be mistaken for a tumor. Therefore, it is important that physicians carefully analyze all "pituitary tumors" removed from patients with acromegaly in order not to overlook the possibility that a tumor elsewhere in the body is causing the disorder.

Complications

Diagnosis

Frequent blood sampling with serum GH measurement shows that in normal subjects (left panel) GH can fluctuate between undetectable levels (most of the time) and peaks of up to 30 μg/l (90 mIU/l), owing to the episodic nature of GH secretion, while in patients with acromegaly (an example is given on right panel), GH hypersecretion is continuous and GH never returns to undetectable levels.

If acromegaly is suspected, medical imaging and medical laboratory investigations are generally used together to confirm or rule out the presence of this condition.

IGF1 provides the most sensitive lab test for the diagnosis of acromegaly, and a GH suppression test following an oral glucose load, which is a very specific lab test, will confirm the diagnosis following a positive screening test for IGF1. A single value of the growth hormone (GH) is not useful in view of its pulsatality (levels in the blood vary greatly even in healthy individuals).

Magnetic resonance image of a pituitary macroadenoma that caused acromegaly with compression of the optic chiasm.

GH levels taken 2 hours after a 75 or 100 gram glucose tolerance test are helpful in the diagnosis: GH levels are suppressed below 1 μg/L in normal people, and levels higher than this cutoff are confirmatory of acromegaly.

Other pituitary hormones have to be assessed to address the secretory effects of the tumor as well as the mass effect of the tumor on the normal pituitary gland. They include TSH (thyroid stimulating hormone), gonadotropic hormones (FSH, LH), ACTH (adrenocorticotropic hormone), prolactin.

An MRI of the brain focusing on the sella turcica after gadolinium administration allows for clear delineation of the pituitary and the hypothalamus and the location of the tumor.

Treatment

The goals of treatment are to reduce GH production to normal levels, to relieve the pressure that the growing pituitary tumor exerts on the surrounding brain areas, to preserve normal pituitary function, and to reverse or ameliorate the symptoms of acromegaly. Currently, treatment options include surgical removal of the tumor, drug therapy, and radiation therapy of the pituitary.

Drugs

Somatostatin analogues

Site of action of the different therapeutic tools in acromegaly. Surgery, radiotherapy, somatostatin analogues and dopamine agonists act at the level of the pituitary adenoma, while GH-receptor antagonists act in periphery by blocking the growth hormone receptor and thus impairing the effects of GH on the different tissues.

The primary current medical treatment of acromegaly is to use somatostatin analogues – octreotide (Sandostatin) or lanreotide (Somatuline). These somatostatin analogues are synthetic forms of a brain hormone, somatostatin, which stops GH production. The long-acting forms of these drugs must be injected every 2 to 4 weeks for effective treatment. Most patients with acromegaly respond to this medication. In many patients, GH levels fall within one hour and headaches improve within minutes after the injection. Octreotide and lanreotide are effective for long-term treatment. Octreotide and lanreotide have also been used successfully to treat patients with acromegaly caused by non-pituitary tumors.

Somatostatin analogues are also sometimes used to shrink large tumors before surgery.

Because octreotide inhibits gastrointestinal and pancreatic function, long-term use causes digestive problems such as loose stools, nausea, and gas in one third of patients. In addition, approximately 25 percent of patients develop gallstones, which are usually asymptomatic. In some cases, octreotide treatment can cause diabetes due to the fact that somatostatin and its analogues can inhibit the release of insulin. On the other hand, scientists have found that in some acromegaly patients who already have diabetes, octreotide can reduce the need for insulin and improve blood sugar control.

Dopamine agonists

For those who are unresponsive to somatostatin analogues, or for whom they are otherwise contraindicated, it is possible to treat using one of the dopamine agonists, Bromocriptine (Parlodel) or Cabergoline. These have the advantage of being tablets rather than injections, and cost considerably less. These drugs can also be used as an adjunct to somatostatin analogue therapy. They are most effective in those whose pituitary tumours cosecrete prolactin. Side effects of these dopamine agonists include gastrointestinal upset, nausea, vomiting, light-headedness when standing, and nasal congestion. These side effects can be reduced or eliminated if medication is started at a very low dose at bedtime, taken with food, and gradually increased to the full therapeutic dose. However, bromocriptine lowers GH and IGF-1 levels and reduces tumor size in fewer than half of patients with acromegaly. Some patients report improvement in their symptoms although their GH and IGF-1 levels still are elevated.

Growth hormone receptor antagonists

The latest development in the medical treatment of acromegaly is the use of growth hormone receptor antagonists. The only available member of this family is pegvisomant (Somavert). By blocking the action of the endogenous growth hormone molecules, this compound is able to control disease activity of acromegaly in virtually all patients. Pegvisomant has to be administered subcutaneously by daily injections. Combinations of long-acting somatostatin analogues and weekly injections of pegvisomant seem to be equally effective as daily injections of pegvisomant.

Surgery

Surgery is a rapid and effective treatment, of which there are two alternative methods. The first method, a procedure known as Endonasal Transphenoidal surgery, involves the surgeon reaching the pituitary through an incision in the nasal cavity wall. The wall is reached by passing through the nostrils with microsurgical instruments. The second method is Transsphenoidal surgery during which an incision is made into the gum beneath the upper lip. Further incisions are made to cut through the septum to reach the nasal cavity, where the pituitary is located. Endonasal Transphenoidal surgery is a less invasive procedure with a shorter recovery time than the older method of Transphenoidal surgery, and the likelihood of removing the entire tumor is greater with reduced side-effects. Consequently, Endonasal Transphenoidal surgery is often used as a first option, with Transphenoidal and other treatments, such as medicinal therapy or radiostatic neurosurgery, being used to reduce the remaining adverse effects of the remaining tumor.

These procedures normally relieve the pressure on the surrounding brain regions and lead to a lowering of GH levels. Surgery is most successful in patients with blood GH levels below 40 ng/ml before the operation and with pituitary tumors no larger than 10 mm in diameter. Success depends on the skill and experience of the surgeon. The success rate also depends on what level of GH is defined as a cure. The best measure of surgical success is normalization of GH and IGF-1 levels. Ideally, GH should be less than 2 ng/ml after an oral glucose load. A review of GH levels in 1,360 patients worldwide immediately after surgery revealed that 60 percent had random GH levels below 5 ng/ml. Complications of surgery may include cerebrospinal fluid leaks, meningitis, or damage to the surrounding normal pituitary tissue, requiring lifelong pituitary hormone replacement.

Even when surgery is successful and hormone levels return to normal, patients must be carefully monitored for years for possible recurrence. More commonly, hormone levels may improve, but not return completely to normal. These patients may then require additional treatment, usually with medications.

Radiation therapy

Radiation therapy has been used both as a primary treatment and combined with surgery or drugs. It is usually reserved for patients who have tumor remaining after surgery. These patients often also receive medication to lower GH levels. Radiation therapy is given in divided doses over four to six weeks. This treatment lowers GH levels by about 50 percent over 2 to 5 years. Patients monitored for more than 5 years show significant further improvement. Radiation therapy causes a gradual loss of production of other pituitary hormones with time. Loss of vision and brain injury, which have been reported, are very rare complications of radiation treatments.

Choice of treatment

No single treatment is effective for all patients. Treatment should be individualized depending on patient characteristics, such as age and tumor size. If the tumor has not yet invaded surrounding brain tissues, removal of the pituitary adenoma by an experienced neurosurgeon is usually the first choice. After surgery, a patient must be monitored for a long time for increasing GH levels. If surgery does not normalize hormone levels or a relapse occurs, a doctor will usually begin additional drug therapy. The current first choice is generally octreotide or lanreotide. However, bromocriptine or cabergoline are much cheaper and easier to administer. With both types of medication, long-term therapy is necessary because their withdrawal can lead to rising GH levels and tumor re-expansion. Radiation therapy is generally used for patients whose tumors are not completely removed by surgery; for patients who are not good candidates for surgery because of other health problems; and for patients who do not respond adequately to surgery and medication.

Prognosis upon treatment

Upon successful treatment, symptoms and complications generally improve substantially or disappear, including headaches, visual disturbances, excess sweating and diabetes.[4] Soft tissue swellings generally decrease and acromegaly-associated facial features gradually return towards normal although this may take some time.[4] Life expectancy after the successful treatment of early acromegaly is equal to that of the normal population.[4]

Pseudoacromegaly

Pseudoacromegaly is a condition with the usual acromegaloid features but without an increase in growth hormone and IGF-1. It is frequently associated with insulin resistance.[5] Cases have been reported due to minoxidil at an unusually high dose.[6]

Notable cases

Famous patients, all but four (Abraham Lincoln, Maurice Tillet, Wallace Stevens, and Antonio Silva) standing in excess of 2.00 metres (6.6 feet). Note: If acromegaly is developed in teenage years, it’s called gigantism and results in excess height. However, when acromegaly commences in adulthood, the bones have already set and the body doesn’t usually grow taller.

  • Kevyn Aucoin, famous celebrity make-up artist, was said to have had a rare pituitary tumor. He had been suffering from acromegaly resulting from the tumor for much of his life, but it had gone undiagnosed. Aucoin died on May 7, 2002 at Westchester Medical Center in Valhalla, New York of kidney and liver failure.
  • Charles Byrne, also known as The Irish Giant, 2.31m (7' 7").
  • Primo Carnera, professional boxer, wrestler, and World Heavyweight champion, 200 cm (6' 7").[7]
  • Ted Cassidy, best known for playing Lurch on The Addams Family (TV series).
  • Dalip Singh Rana a/k/a The Great Khali, Professional wrestler, actor, former police officer, 7 ft 1 in (2.16 m).
  • Rondo Hatton, character horror actor in the 1930s and 1940s[8]
  • Richard Kiel, Jaws from the James Bond Movies and Mr. Larson in Happy Gilmore.[9] He grew up to 7ft 1 1/2 but is now slightly under 7ft due to age and injury
  • Abraham Lincoln, the 16th President of the United States, was debated at several occasions to have Marfan's syndrome and also acromegaly.[10][11] He grew to 1.93 m (6 ft. 4 in) in height and generally weighed less than 82 kg (180 lb). Lincoln's body growth and energic constitution show gross evidence of pituitary hyperactivity and gonadal hypoactivity. He was a long, thin baby at birth, with unusually long, thin arms and legs.
  • Cornelius Magrath, known as The Irish Giant.
  • Maximinus I, Roman Emperor from 235 to 238.
  • James McLeay, professional SANFL player, suffers from low grade acromegaly, 2.1 m, 120 kilograms.[12]
  • Pío Pico, the last Mexican Governor of California (1801–1894), manifested acromegaly without gigantism between at least 1847 and 1858. Some time after 1858 signs of the growth hormone-producing tumor disappeared along with all the secondary effects the tumor had caused in him. He looked normal in his 90's.[13] His remarkable recovery is likely an example of spontaneous selective pituitary tumor apoplexy.[14]
  • Anthony Robbins, motivational speaker.
  • André René Roussimoff a/k/a André the Giant, wrestler and actor [15][16] 2.13 m (7') tall after back surgery; his original wrestling stats listed him at 2.23 m (7'4"). He died at the age of 46 and weighed 520 pounds (240 kg). (He chose not to be treated and died from cardiac complications of the disease.)
  • Antonio Silva, mixed martial artist, currently competing at heavyweight in the Ultimate Fighting Championship. Silva has a professional record of 18-4, with 13 of his 18 wins coming by way of Knockout. Silva stands at 6'4 and weighs in for fights at 264 lbs.
  • Sir Archibald Levin Smith, British judge,[17]
  • Carel Struycken, Actor, 2.13m (7'0").[18]
  • Nikolai Valuev, the tallest (7' or 2.1 m) and heaviest champion in boxing history.[19]
  • Paul "The Big Show" Wight, wrestler, also known as "The Big Show" or "The Giant". Stands 7' or 2.1 m[20]
  • John Bloom best known for his role in Bachelor Party as Milt, the Indian pimp's enforcer and bodyguard.
  • Kevin Strootman Soccerplayer |PSV eindhoven], currently active in the Dutch national team.
  • Neil McCarthy Classic British actor, known for his craggy looks, died of motor neurone disease.



Fictional

References

  1. ^ "Acromegaly and Gigantism". Merck.com. Archived from the original on 5 November 2010. Retrieved 2010-10-26. {{cite web}}: Unknown parameter |deadurl= ignored (|url-status= suggested) (help)
  2. ^ James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.
  3. ^ Renehan AG, O'Connell J, O'Halloran D; et al. (2003). "Acromegaly and colorectal cancer: a comprehensive review of epidemiology, biological mechanisms, and clinical implications". Horm. Metab. Res. 35 (11–12): 712–25. doi:10.1055/s-2004-814150. PMID 14710350. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  4. ^ a b c Acromegaly - Patient information from Centre for Diabetes and Endocrinology at The Royal Berkshire NHS Foundation Trust. January 2011
  5. ^ Yaqub A, Yaqub N (2008). "Insulin-mediated pseudoacromegaly: a case report and review of the literature". W V Med J. 104 (5): 12–5. PMID 18846753.
  6. ^ Nguyen KH, Marks JG (2003). "Pseudoacromegaly induced by the long-term use of minoxidil". J. Am. Acad. Dermatol. 48 (6): 962–5. doi:10.1067/mjd.2003.325. PMID 12789195. {{cite journal}}: Unknown parameter |month= ignored (help)
  7. ^ "Boxer vs. Wrestler Primo Carnera". Mmbolding.com. Retrieved 2012-06-08.
  8. ^ "Rondo Hatton by Barry Brown". Barrybrown.info. Retrieved 2010-07-26.
  9. ^ "Richard "Jaws" Kiel, Famed Bond Movie Villain, Raises Awareness Oflife-Threatening Hormone Disorder". Prnewswire.com. Retrieved 2010-07-26.
  10. ^ Link text, Historical footnote in regards to Marfan's.
  11. ^ Link text, Hypokinetic Constitution.
  12. ^ [1][dead link]
  13. ^ Login IS, Login J (2008). "Governor Pio Pico, the monster of California...no more: lessons in neuroendocrinology". Pituitary. 13 (1): 80–6. doi:10.1007/s11102-008-0127-1. PMC 2807602. PMID 18597174. {{cite journal}}: Unknown parameter |month= ignored (help) Open Access; http://www.springerlink.com/content/u7645787h2435373/fulltext.pdf
  14. ^ Nawar RN, AbdelMannan D, Selman WR, Arafah BM (2008). "Pituitary tumor apoplexy: a review". J Intensive Care Med. 23 (2): 75–90. doi:10.1177/0885066607312992. PMID 18372348.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  15. ^ "Andre the Giant: Bio". WWE.com. Archived from the original on 2008-01-10. Retrieved 2007-10-16.
  16. ^ "André the Giant official website". Archived from the original on 4 July 2007. Retrieved 2007-07-08. {{cite web}}: Unknown parameter |deadurl= ignored (|url-status= suggested) (help)
  17. ^ "Famous Acromegalics and Our Member Photos". Acromegalycommunity.com. Retrieved 2010-07-26.
  18. ^ Carel Struycken - IMDb
  19. ^ 7-foot giant claims WBA heavyweight title – Boxing- NBC Sports. Nbcsports.msnbc.com (2005-12-17). Retrieved on 2011-04-19.
  20. ^ Levitt, Stephanie (1972-02-08). "The show must go on: in basketball, professional wrestling and life in general, Paul Wight has had his share of triumphs and disappointment | Wrestling Digest | Find Articles at BNET". Findarticles.com. Retrieved 2010-07-26. [dead link]
  21. ^ "report on Punch and Acromegaly". BBC News. 2006-09-05. Retrieved 2010-10-26.
  22. ^ World of Wonders. Robertson Davies. Penguin books, 1975; pp282-3.

This template is no longer used; please see Template:Endocrine pathology for a suitable replacement