Addressin

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MADCAM1
1BQS.pdb.png
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases MADCAM1, MACAM1, mucosal vascular addressin cell adhesion molecule 1
External IDs GeneCards: 8174
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_130762
NM_130760

n/a

RefSeq (protein)

NP_570116.2
NP_570118.1

n/a

Location (UCSC) Chr 19: 0.49 – 0.51 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

Addressin also known as mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) is a protein that in humans is encoded by the MADCAM1 gene.[2][3][4]

Addressin is an extracellular protein of the endothelium of venules. Addressins are the ligands to the homing receptors of lymphocytes.[5] The task of these ligands and their receptors is to determine which tissue the lymphocyte will enter next. They carry carbohydrates in order to be recognized by L-selectin.

Function[edit]

The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4 / beta7), L-selectin, and VLA-4 (alpha4 / beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin superfamily and is similar to ICAM-1 and VCAM-1.[2]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ a b "Entrez Gene: mucosal vascular addressin cell adhesion molecule 1". 
  3. ^ Shyjan AM, Bertagnolli M, Kenney CJ, Briskin MJ (April 1996). "Human mucosal addressin cell adhesion molecule-1 (MAdCAM-1) demonstrates structural and functional similarities to the alpha 4 beta 7-integrin binding domains of murine MAdCAM-1, but extreme divergence of mucin-like sequences". J. Immunol. 156 (8): 2851–7. PMID 8609404. 
  4. ^ Leung E, Berg RW, Langley R, Greene J, Raymond LA, Augustus M, Ni J, Carter KC, Spurr N, Choo KH, Krissansen GW (1997). "Genomic organization, chromosomal mapping, and analysis of the 5' promoter region of the human MAdCAM-1 gene". Immunogenetics. 46 (2): 111–9. doi:10.1007/s002510050249. PMID 9162097. 
  5. ^ Addressin at eMedicine Dictionary

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.