Addressin

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MADCAM1
1BQS.pdb.png
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesMADCAM1, MACAM1, mucosal vascular addressin cell adhesion molecule 1
External IDsGeneCards: MADCAM1
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for MADCAM1
Genomic location for MADCAM1
Band19p13.3Start489,176 bp[1]
End505,342 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_130762
NM_130760

n/a

RefSeq (protein)

NP_570116
NP_570118

n/a

Location (UCSC)Chr 19: 0.49 – 0.51 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Addressin also known as mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) is a protein that in humans is encoded by the MADCAM1 gene.[3][4][5]

Addressin is an extracellular protein of the endothelium of venules.

Addressins are the ligands to the homing receptors of lymphocytes.[6] The task of these ligands and their receptors is to determine which tissue the lymphocyte will enter next. They carry carbohydrates in order to be recognized by L-selectin.

Function[edit]

The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4 / beta7), L-selectin, and VLA-4 (alpha4 / beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin superfamily and is similar to ICAM-1 and VCAM-1.[3]

In terms of migration, MADCAM is selectively expressed on mucosal endothelial cells, driving memory T-cell re-circulation through mucosal tissues. In contrast, and indeed the main difference between the two molecules, ICAM molecules are involved with naive T-cell re-circulation. Whereas MADCAM is selectively expressed, ICAM is broadly expressed on inflamed endothelium.

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000099866 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". 
  3. ^ a b "Entrez Gene: mucosal vascular addressin cell adhesion molecule 1". 
  4. ^ Shyjan AM, Bertagnolli M, Kenney CJ, Briskin MJ (April 1996). "Human mucosal addressin cell adhesion molecule-1 (MAdCAM-1) demonstrates structural and functional similarities to the alpha 4 beta 7-integrin binding domains of murine MAdCAM-1, but extreme divergence of mucin-like sequences". J. Immunol. 156 (8): 2851–7. PMID 8609404. 
  5. ^ Leung E, Berg RW, Langley R, Greene J, Raymond LA, Augustus M, Ni J, Carter KC, Spurr N, Choo KH, Krissansen GW (1997). "Genomic organization, chromosomal mapping, and analysis of the 5' promoter region of the human MAdCAM-1 gene". Immunogenetics. 46 (2): 111–9. doi:10.1007/s002510050249. PMID 9162097. 
  6. ^ Addressin at eMedicine Dictionary

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.