Alanine—oxo-acid transaminase

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alanine-oxo-acid transaminase
Identifiers
EC number2.6.1.12
CAS number9030-41-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, an alanine-oxo-acid transaminase (EC 2.6.1.12) is an enzyme that catalyzes the chemical reaction

L-alanine + a 2-oxo acid pyruvate + an L-amino acid

Thus, the two substrates of this enzyme are L-alanine and 2-oxo acid, whereas its two products are pyruvate and L-amino acid.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is L-alanine:2-oxo-acid aminotransferase. Other names in common use include L-alanine-alpha-keto acid aminotransferase, leucine-alanine transaminase, alanine-keto acid aminotransferase, and alanine-oxo acid aminotransferase. This enzyme participates in alanine and aspartate metabolism. It employs one cofactor, pyridoxal phosphate.

References[edit]

  • ALTENBERN RA, HOUSEWRIGHT RD (1953). "Transaminases in smooth Brucella abortus, strain 19" (PDF). J. Biol. Chem. 204 (1): 159–67. PMID 13084587.
  • Rowsell EV (1956). "Transaminations with pyruvate and other alpha-keto acids". Biochem. J. 64 (2): 246–252. PMC 1199724. PMID 13363834.
  • Sallach HJ (1956). "Formation of serine from hydroxypyruvate and L-alanine" (PDF). J. Biol. Chem. 223 (2): 1101–1108.
  • Wilson DG, King KW, Burris RH (1954). "Transaminase reactions in plants" (PDF). J. Biol. Chem. 208 (2): 863–874.