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ICD-9-CM 75.37

Amnioinfusion is a method in which isotonic fluid is instilled into the amniotic cavity in order to thin thick meconium that has passed into the amniotic fluid.

It has been used to reduce meconium aspiration syndrome, though evidence of benefit is mixed.[1][2] It also serves to possibly prevent or relieve cord compression.[3]

It is sometimes used in severe cases of oligohydramnios to prevent umbilical cord compression.[4] However, there is uncertainty about the procedure's safety and efficacy, and it is recommended that it should only be performed in centres specialising in invasive fetal medicine and in the context of a multidisciplinary team.[5]


Complications with amnioinfusion are extremely rare. There are case reports of maternal amniotic fluid embolism, but a clear causal relationship has not been demonstrated.[6]


  1. ^ Fraser WD, Hofmeyr J, Lede R, et al. (September 2005). "Amnioinfusion for the prevention of the meconium aspiration syndrome". N. Engl. J. Med. 353 (9): 909–17. doi:10.1056/NEJMoa050223. PMID 16135835. 
  2. ^ Edwards RK, Duff P (1999). "Prophylactic cefazolin in amnioinfusions administered for meconium-stained amniotic fluid". Infect Dis Obstet Gynecol. 7 (3): 153–7. doi:10.1155/S1064744999000241. PMC 1784731Freely accessible. PMID 10371474. 
  3. ^ Hofmeyr GJ, Xu H, Eke AC. Amnioinfusion for meconium-stained liquor in labour. Cochrane Database Syst Rev 2014; 1:CD000014.
  4. ^ Hsu TL, Hsu TY, Tsai CC, Ou CY (December 2007). "The experience of amnioinfusion for oligohydramnios during the early second trimester". Taiwan J Obstet Gynecol. 46 (4): 395–8. doi:10.1016/S1028-4559(08)60009-1. PMID 18182345. 
  5. ^ Oligohydramnios at the National Institute for Health and Clinical Excellence. Based on the overview Therapeutic amnioinfusion for oligohydramnios during pregnancy (excluding labour) in 2006
  6. ^ Roberts WE, Martin RW, Roach HH, et al. Are obstetric interventions such as cervical ripening, induction of labor, amnioinfusion, or amniotomy associated with umbilical cord prolapse? Am J Obstet Gynecol 1997; 176:1181.