- Open fetal surgery involves completely opening the uterus to operate on the fetus.
- Minimally invasive fetoscopic surgery uses small incisions and is guided by fetoscopy and sonography.
Open fetal surgery
Tocolytics are generally given to prevent labor. However, these should not be given if the risk is higher for the fetus inside the womb than if delivered, such as may be the case in intrauterine infection, unexplained vaginal bleeding and fetal distress.
Regarding anesthesia, an H2 antagonist is usually given the evening before and the morning of the operation, and an antacid is usually given before induction to reduce the risk of acid aspiration. Rapid sequence induction is usually used for sedation and intubation.
Open fetal surgery is similar in many respects to a normal cesarean section performed under general anesthesia, except that the fetus remains dependent on the placenta and is returned to the uterus. A hysterotomy is performed on the pregnant woman. Once the uterus is open and the fetus is exposed, the fetal surgery begins. Typically, this surgery consists of an interim procedure intended to allow the fetus to remain in utero until it has matured enough to survive delivery and neonatal surgical procedures.
Upon completion of the fetal surgery, the fetus is put back inside the uterus and the uterus and abdominal wall are closed up. Before the last stitch is made in the uterine wall, the amniotic fluid is replaced.
The mother remains in the hospital for 3–7 days for monitoring and is required to subsequently deliver the baby via a second cesarean section. Often babies who have been operated on in this manner are born pre-term.
Safety and complications
The main priority is maternal safety, and, secondary, avoiding preterm labor and achieving the aims of the surgery. Open fetal surgery is possible first after approximately 18 weeks of gestation due to fetal size and fragility before that, and up to approximately 30 weeks of gestation due to increased risk of premature labor and, practically, the preference for delivering the child and performing the surgery ex utero instead. The risk of premature labor is increased by concomitant risk factors such as multiple gestation, a history of maternal smoking, and very young or old maternal age.
Open fetal surgery has proven to be reasonably safe for the mother. For the fetus, safety and effectiveness are variable, and depend on the specific procedure, the reasons for the procedure, and the gestational age and condition of the fetus. The overall perinatal mortality after open surgery has been estimated to be approximately 6%, according to a study in the United States 2003.
Prenatal repair of neural tube defects such as myelomeningocele and spina bifida is a growing option in the United States. Although the procedure is technically challenging, children treated with open fetal repair have significantly improved outcomes compared to children whose defects are repaired shortly after birth. Specifically, fetal repair reduces the rate of ventriculoperitoneal shunt dependence and Chiari malformation, while improving motor skills at 30 months of age compared to post-natal repair. Children having fetal repair are twice as likely to walk independently at 30 months of age than children undergoing post-natal repair. As a result, open fetal repair of spina bifida is now considered standard of care at fetal specialty centers.
Other conditions that potentially are treated by open fetal surgery include:
- Congenital diaphragmatic hernia (if indicated at all, it is now more likely to be treated by endoscopic fetal surgery)
- Congenital cystic adenomatoid malformation
- Congenital heart disease
- Pulmonary sequestration
- Sacrococcygeal teratoma
Minimally invasive fetal surgery
|This section does not cite any references or sources. (April 2013)|
Minimally-invasive fetoscopic surgery (akin to 'keyhole surgery'has proven to be very useful for some, but not all, fetal conditions.
- Twin-twin transfusion syndrome – Laser Ablation of Vessels
- Spina bifida – Fetoscopic closure of the malformation. Prenatal repair of the spina bifida lesion through this approach has been purported to result in less complications to the mother, whilst affording benefit to the baby. This operation is mostly carried on in Giessen, Germany by Professor Thomas Kohl.
On April 26, 1981, the first human open fetal surgery in the world was performed at University of California, San Francisco under the direction of Dr. Michael Harrison. The fetus in question had a congenital hydronephrosis, a blockage in the urinary tract that caused the kidney to dangerously extend. To correct this a vesicostomy was performed placing a catheter in the fetus allowing the urine to be released normally. The blockage itself was removed surgically after birth.
Further advances have been made in the years since this first operation. New techniques have allowed additional defects to be treated and for less invasive forms of fetal surgical intervention.
- EXIT procedure
- Pediatric surgery
- MOMS Trial
- Spina Bifida
- Samuel Armas
- St. Louis Fetal Care Institute Fetal Surgery
- Sutton LN (February 2008). "Fetal surgery for neural tube defects". Best Pract Res Clin Obstet Gynaecol 22 (1): 175–88. doi:10.1016/j.bpobgyn.2007.07.004. PMC 2293328. PMID 17714997.
- Johnson, M. P.; Sutton, L. N.; Rintoul, N.; Crombleholme, T. M.; Flake, A. W.; Howell, L. J.; Hedrick, H. L.; Wilson, R. D.; Adzick, N. S. (2003). "Fetal myelomeningocele repair: short-term clinical outcomes". American journal of obstetrics and gynecology 189 (2): 482–487. doi:10.1067/S0002-9378(03)00295-3. PMID 14520222.
- Adzick, NS; Thom EA, Spong CY, Brock III JW, Burrows PK, Johnson MP, Howell LJ, Farrell JA, Dabrowiak ME, Sutton LN, Gupta N, Tulipan NB, D'Alton ME, Farmer DL (9 Feb 2011). "A Randomized Trial of Prenatal versus Postnatal Repair of Myelomeningocele". New England Journal of Medicine 364 (11): 993–1004. doi:10.1056/NEJMoa1014379. PMC 3770179. PMID 21306277.
- Degenhardt J et al. Percutaneous minimal-access fetoscopic surgery for spina aperta. Part II: maternal management and outcome. Ultrasound Obstet Gynecol 2014; 44: 525–531
- VERBEEK, RENATE J (2011). "Fetal endoscopic myelomeningocele closure preserves segmental neurological function". Developmental Medicine 54 (1): 15–22. doi:10.1111/j.1469-8749.2011.04148.
- Kohl, Thomas. Percutaneous minimally invasive fetoscopic surgery for spina bifida aperta. Part I: surgical technique and perioperative outcome.Ultrasound Obstet Gynecol 2014; 44: 515–524
- Science 80：Volume 4, issues 1–5. American Association for the Advancement of Science. 1983. pp. ７２. Retrieved April 25, 2011.
- Russell, Sabin (May 5, 2005). "First fetal surgery survivor finally meets his doctor: 24 years ago, UCSF surgeon saved his life in mom's womb". San Francisco Chronicle. Retrieved July 26, 2006.
-  Sutton LN (February 2008). "Fetal surgery for neural tube defects". Best Pract Res Clin Obstet Gynaecol 22 (1): 175–88. doi:10.1016/j.bpobgyn.2007.07.004. PMC 2293328. PMID 17714997.