Aromatic-amino-acid transaminase

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aromatic-amino-acid transaminase
EC number
CAS number 37332-38-0
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, an aromatic-amino-acid transaminase (EC is an enzyme that catalyzes the chemical reaction

an aromatic amino acid + 2-oxoglutarate an aromatic oxo acid + L-glutamate

Thus, the two substrates of this enzyme are aromatic amino acid and 2-oxoglutarate, whereas its two products are aromatic oxo acid and L-glutamate.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is aromatic-amino-acid:2-oxoglutarate aminotransferase. Other names in common use include aromatic amino acid aminotransferase, aromatic aminotransferase, and ArAT. This enzyme participates in 6 metabolic pathways: methionine metabolism, tyrosine metabolism, phenylalanine metabolism, phenylalanine, tyrosine and tryptophan biosynthesis, novobiocin biosynthesis, and alkaloid biosynthesis i. It employs one cofactor, pyridoxal phosphate.

Structural studies[edit]

As of late 2007, 13 structures have been solved for this class of enzymes, with PDB accession codes 1AY4, 1AY5, 1AY8, 2AY1, 2AY2, 2AY3, 2AY4, 2AY5, 2AY6, 2AY7, 2AY8, 2AY9, and 3TAT.


  • Mavrides C, Orr W (1975). "Multispecific aspartate and aromatic amino acid aminotransferases in Escherichia coli". J. Biol. Chem. 250 (11): 4128–33. PMID 236311.