Aromatic-amino-acid transaminase

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aromatic-amino-acid transaminase
Identifiers
EC number 2.6.1.57
CAS number 37332-38-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, an aromatic-amino-acid transaminase (EC 2.6.1.57) is an enzyme that catalyzes the chemical reaction

an aromatic amino acid + 2-oxoglutarate an aromatic oxo acid + L-glutamate

Thus, the two substrates of this enzyme are aromatic amino acid and 2-oxoglutarate, whereas its two products are aromatic oxo acid and L-glutamate.

This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is aromatic-amino-acid:2-oxoglutarate aminotransferase. Other names in common use include aromatic amino acid aminotransferase, aromatic aminotransferase, and ArAT. This enzyme participates in 6 metabolic pathways: methionine metabolism, tyrosine metabolism, phenylalanine metabolism, phenylalanine, tyrosine and tryptophan biosynthesis, novobiocin biosynthesis, and alkaloid biosynthesis i. It employs one cofactor, pyridoxal phosphate.

Structural studies[edit]

As of late 2007, 13 structures have been solved for this class of enzymes, with PDB accession codes 1AY4, 1AY5, 1AY8, 2AY1, 2AY2, 2AY3, 2AY4, 2AY5, 2AY6, 2AY7, 2AY8, 2AY9, and 3TAT.

References[edit]

  • Mavrides C, Orr W (1975). "Multispecific aspartate and aromatic amino acid aminotransferases in Escherichia coli". J. Biol. Chem. 250 (11): 4128–33. PMID 236311.