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Proline-rich coiled-coil 2A
Symbols PRRC2A ; BAT2; D6S51; D6S51E; G2
External IDs OMIM142580 MGI1915467 HomoloGene10567 GeneCards: PRRC2A Gene
RNA expression pattern
PBB GE BAT2 208132 x at tn.png
PBB GE BAT2 212081 x at tn.png
PBB GE BAT2 214201 x at tn.png
More reference expression data
Species Human Mouse
Entrez 7916 53761
Ensembl ENSG00000204469 ENSMUSG00000024393
UniProt P48634 Q7TSC1
RefSeq (mRNA) NM_004638 NM_001199044
RefSeq (protein) NP_004629 NP_001185973
Location (UCSC) Chr 6:
31.62 – 31.64 Mb
Chr 17:
35.15 – 35.16 Mb
PubMed search [1] [2]

Large proline-rich protein BAT2 is a protein that in humans is encoded by the BAT2 gene.[1][2][3]


A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all within the human major histocompatibility complex class III region. This gene has microsatellite repeats which are associated with the age-at-onset of insulin-dependent diabetes mellitus (IDDM) and possibly thought to be involved with the inflammatory process of pancreatic beta-cell destruction during the development of IDDM. This gene is also a candidate gene for the development of rheumatoid arthritis. There are two alternatively spliced transcripts encoding different isoforms described for this gene.[3]


BAT2 has been shown to interact with:


  1. ^ Banerji J, Sands J, Strominger JL, Spies T (Apr 1990). "A gene pair from the human major histocompatibility complex encodes large proline-rich proteins with multiple repeated motifs and a single ubiquitin-like domain". Proc Natl Acad Sci U S A 87 (6): 2374–8. doi:10.1073/pnas.87.6.2374. PMC 53689. PMID 2156268. 
  2. ^ Iris FJ, Bougueleret L, Prieur S, Caterina D, Primas G, Perrot V, Jurka J, Rodriguez-Tome P, Claverie JM, Dausset J; et al. (Jun 1993). "Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment". Nat Genet 3 (2): 137–45. doi:10.1038/ng0293-137. PMID 8499947. 
  3. ^ a b "Entrez Gene: BAT2 HLA-B associated transcript 2". 
  4. ^ a b c d e f Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (Jan 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819. 

Further reading[edit]