BAT2

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PRRC2A
Identifiers
Aliases PRRC2A, BAT2, D6S51, D6S51E, G2, proline rich coiled-coil 2A
External IDs MGI: 1915467 HomoloGene: 10567 GeneCards: PRRC2A
RNA expression pattern
PBB GE BAT2 208132 x at tn.png

PBB GE BAT2 212081 x at tn.png

PBB GE BAT2 214201 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004638
NM_080686

NM_001199044
NM_020027

RefSeq (protein)

NP_004629
NP_542417

NP_001185973.1
NP_064411.2
NP_001185973
NP_064411

Location (UCSC) Chr 6: 31.62 – 31.64 Mb Chr 17: 35.15 – 35.16 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Large proline-rich protein BAT2 is a protein that in humans is encoded by the BAT2 gene.[3][4][5]

Function[edit]

A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for TNF alpha and TNF beta. These genes are all within the human major histocompatibility complex class III region. This gene has microsatellite repeats which are associated with the age-at-onset of insulin-dependent diabetes mellitus (IDDM) and possibly thought to be involved with the inflammatory process of pancreatic beta-cell destruction during the development of IDDM. This gene is also a candidate gene for the development of rheumatoid arthritis. There are two alternatively spliced transcripts encoding different isoforms described for this gene.[5]

Interactions[edit]

BAT2 has been shown to interact with:

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Banerji J, Sands J, Strominger JL, Spies T (Apr 1990). "A gene pair from the human major histocompatibility complex encodes large proline-rich proteins with multiple repeated motifs and a single ubiquitin-like domain". Proc Natl Acad Sci U S A. 87 (6): 2374–8. doi:10.1073/pnas.87.6.2374. PMC 53689Freely accessible. PMID 2156268. 
  4. ^ Iris FJ, Bougueleret L, Prieur S, Caterina D, Primas G, Perrot V, Jurka J, Rodriguez-Tome P, Claverie JM, Dausset J, et al. (Jun 1993). "Dense Alu clustering and a potential new member of the NF kappa B family within a 90 kilobase HLA class III segment". Nat Genet. 3 (2): 137–45. doi:10.1038/ng0293-137. PMID 8499947. 
  5. ^ a b "Entrez Gene: BAT2 HLA-B associated transcript 2". 
  6. ^ a b c d e f Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (Jan 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819. 

External links[edit]

Further reading[edit]