BRE (gene)

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Brain and reproductive organ-expressed (TNFRSF1A modulator)
Identifiers
Symbols BRE ; BRCC4; BRCC45
External IDs OMIM610497 MGI1333875 HomoloGene3604 GeneCards: BRE Gene
RNA expression pattern
PBB GE BRE 205550 s at tn.png
PBB GE BRE 211566 x at tn.png
PBB GE BRE 212645 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9577 107976
Ensembl ENSG00000158019 ENSMUSG00000052139
UniProt Q9NXR7 Q8K3W0
RefSeq (mRNA) NM_001261840 NM_144541
RefSeq (protein) NP_001248769 NP_653124
Location (UCSC) Chr 2:
27.89 – 28.34 Mb
Chr 5:
31.7 – 32.08 Mb
PubMed search [1] [2]

BRCA1-A complex subunit BRE is a protein that in humans is encoded by the BRE gene.[1][2][3]

Interactions[edit]

BRE (gene) has been shown to interact with:

References[edit]

  1. ^ Gu C, Castellino A, Chan JY, Chao MV (Sep 1998). "BRE: a modulator of TNF-alpha action". FASEB Journal 12 (12): 1101–8. PMID 9737713. 
  2. ^ Li L, Yoo H, Becker FF, Ali-Osman F, Chan JY (Jan 1995). "Identification of a brain- and reproductive-organs-specific gene responsive to DNA damage and retinoic acid". Biochemical and Biophysical Research Communications 206 (2): 764–74. doi:10.1006/bbrc.1995.1108. PMID 7826398. 
  3. ^ "Entrez Gene: BRE brain and reproductive organ-expressed (TNFRSF1A modulator)". 
  4. ^ a b c d e f Dong Y, Hakimi MA, Chen X, Kumaraswamy E, Cooch NS, Godwin AK, Shiekhattar R (Nov 2003). "Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair". Molecular Cell 12 (5): 1087–99. PMID 14636569. 
  5. ^ a b Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S et al. "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 
  6. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

Further reading[edit]

  • Miao J, Panesar NS, Chan KT, Lai FM, Xia N, Wang Y, Johnson PJ, Chan JY (Apr 2001). "Differential expression of a stress-modulating gene, BRE, in the adrenal gland, in adrenal neoplasia, and in abnormal adrenal tissues". The Journal of Histochemistry and Cytochemistry 49 (4): 491–500. doi:10.1177/002215540104900409. PMID 11259452. 
  • Ching AK, Li PS, Li Q, Chan BC, Chan JY, Lim PL, Pang JC, Chui YL (Nov 2001). "Expression of human BRE in multiple isoforms". Biochemical and Biophysical Research Communications 288 (3): 535–45. doi:10.1006/bbrc.2001.5801. PMID 11676476. 
  • Dong Y, Hakimi MA, Chen X, Kumaraswamy E, Cooch NS, Godwin AK, Shiekhattar R (Nov 2003). "Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair". Molecular Cell 12 (5): 1087–99. doi:10.1016/S1097-2765(03)00424-6. PMID 14636569. 
  • Li Q, Ching AK, Chan BC, Chow SK, Lim PL, Ho TC, Ip WK, Wong CK, Lam CW, Lee KK, Chan JY, Chui YL (Dec 2004). "A death receptor-associated anti-apoptotic protein, BRE, inhibits mitochondrial apoptotic pathway". The Journal of Biological Chemistry 279 (50): 52106–16. doi:10.1074/jbc.M408678200. PMID 15465831. 
  • Chan BC, Li Q, Chow SK, Ching AK, Liew CT, Lim PL, Lee KK, Chan JY, Chui YL (Jan 2005). "BRE enhances in vivo growth of tumor cells". Biochemical and Biophysical Research Communications 326 (2): 268–73. doi:10.1016/j.bbrc.2004.11.013. PMID 15582573. 
  • Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (May 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.