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BRINP3

From Wikipedia, the free encyclopedia
BRINP3
Identifiers
AliasesBRINP3, DBCCR1L, DBCCR1L1, FAM5C, BMP/retinoic acid inducible neural specific 3
External IDsOMIM: 618390; MGI: 2443035; HomoloGene: 17786; GeneCards: BRINP3; OMA:BRINP3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_199051
NM_001317188

NM_001145807
NM_153539
NM_001357571
NM_001357572

RefSeq (protein)

NP_001304117
NP_950252

NP_001139279
NP_705767
NP_001344500
NP_001344501

Location (UCSC)Chr 1: 190.1 – 190.48 MbChr 1: 146.37 – 146.78 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

BMP/retinoic acid inducible neural specific 3 is a protein that in humans is encoded by the BRINP3 gene. [5]

Function

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This gene is overexpressed in pituitary tumors but is underexpressed in tongue squamous cell carcinomas, ulcerative colitis, and peri-implantitis. Polymorphisms that increase expression of this gene have been shown to increase vascular inflammation, and an association of this gene with myocardial infarction has been demonstrated. Finally, hypermethylation of this gene may find usefulness as a biomarker for gastric cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015].

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162670Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035131Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: BMP/retinoic acid inducible neural specific 3". Retrieved 2018-08-03.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.