BTBD2

From Wikipedia, the free encyclopedia
Jump to: navigation, search
BTBD2
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases BTBD2, BTB domain containing 2
External IDs MGI: 1933831 HomoloGene: 32365 GeneCards: BTBD2
RNA expression pattern
PBB GE BTBD2 207722 s at fs.png

PBB GE BTBD2 gnf1h01352 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_017797

NM_145361

RefSeq (protein)

NP_060267

n/a

Location (UCSC) Chr 19: 1.99 – 2.03 Mb Chr 10: 80.64 – 80.66 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

BTB/POZ domain-containing protein 2 is a protein that in humans is encoded by the BTBD2 gene.[3][4]

Function[edit]

The C-terminus of the protein encoded by this gene binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), both of which are typically involved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic bodies.[4]

Interactions[edit]

BTBD2 has been shown to interact with TOP1.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Carim-Todd L, Sumoy L, Andreu N, Estivill X, Escarceller M (Jan 2001). "Identification and characterization of BTBD1, a novel BTB domain containing gene on human chromosome 15q24". Gene. 262 (1-2): 275–81. doi:10.1016/S0378-1119(00)00513-8. PMID 11179693. 
  4. ^ a b "Entrez Gene: BTBD2 BTB (POZ) domain containing 2". 
  5. ^ Xu L, Yang L, Hashimoto K, Anderson M, Kohlhagen G, Pommier Y, D'Arpa P (2002). "Characterization of BTBD1 and BTBD2, two similar BTB-domain-containing Kelch-like proteins that interact with Topoisomerase I". BMC Genomics. 3: 1. doi:10.1186/1471-2164-3-1. PMC 64781Freely accessible. PMID 11818025. 

External links[edit]

Further reading[edit]