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Bison/Domestic cattle hybrids
The American bison and European bison (wisent) have been hybridized with Domestic Cattle. With wisent, this was originally done in an attempt to reinvigorate the declining wisent population. First generation hybrid males are sterile, but females may be crossed back to either a wisent or domestic bull to produce fertile males. Modern wisent herds keep hybrids well isolated from pure wisent. However, since the modern purebred wisent are descended from less than 2 dozen individuals, this has resulted in a significant genetic bottleneck for the purebred wisent.
European bison (Wisent) have also been crossed with domestic cattle to produce the żubroń. These were first bred in Poland in 1847 as hardy, disease resistant alternatives to domestic cattle. Breeding was discontinued in the 1980s. The few remaining zubron can be found at Bialowieski National Park.
American bison bulls (American "buffalo") have been crossed with domestic cattle to produce beefalo and cattalo. These are variable in type and colour, depending on the breed of cattle used e.g. Herefords and Charolais (beef cattle), Holsteins (dairy) or Brahman (humped cattle). Generally, they are horned with heavy set forequarters, sloping backs and lighter hindquarters. Beefalo have been back-crossed to bison and to domestic cattle; some of these resemble pied bison with smooth coats and a maned hump. The aim is to produce high protein, low fat and low cholesterol beef on animals which have "less hump and more rump". Although bison bull/domestic cow crossings are more usual, domestic bull/bison cow crossings have a lower infant mortality rate (cow immune systems can reject hybrid calves). Modern beefalo include fertile bulls, making the beefalo a variety of "improved cattle" with a dash of bison. There were suggestions of crossing the beefalo to Cape buffalo, although this idea essentially ended when the Cape buffalo was found to have 52 chromosomes (instead of 60 as in cattle and bison), meaning that the hybrid's success would be unlikely. Bull and cow cattalos are reported in Wonders of Animal Life edited by J A Hammerton (1930).
Mitochondrial DNA testing of the Custer State Park herd have shown that 6% of the animals have bovine DNA traits and Dr Derr from Texas A&M University, who lead a study into bison genetics, conceded that the ‘hybrid’ animals tested were at least 15-20 generations from the original base stock and those animals contained only 0.003% bovine DNA. This herd was started in 1901 with a relatively small number of animals (<30). At the time, all these animals were believed to be pure through analysis of the physical phenotype but at least one animal with some bovine DNA must have been included in the original herd. Since the herd was formed, no new animals have been introduced and in this closed genetic pool, bovine DNA influences have not exceeded 6%, despite numerous generations of animals having passed. It is not yet known why this bovine DNA has not influenced a greater proportion of the herd nor a higher percentage of bovine DNA having survived, but one theory is that pure-bred animals with bovine influence do not grow to be as competitive as full-blood animals and are less likely to become dominant herd bulls. Therefore, the hybrid animals bulls are less likely to reproduce in the wild than pure animals, limiting the spread of bovine DNA within the herd.
Not all public herds in the US and Canada have been tested for bovine DNA but the Elk Island Plains Bison Herd in Canada has been tested as pure. Other public herds that are believed pure include the Yellowstone Park Bison Herd, the Henry Mountains Bison Herd and the Wind Cave Bison Herd.
Since DNA testing for purity has become available, there is a growing movement among bison ranchers to test their herds and cull animals that test positive for bovine DNA. The largest private herd in the world, with over 50,000 animals, is currently undergoing such a program. As similar programs gather momentum among smaller private herds, the level of hybridization among private herds will likely reduce to a very small level as there is no commercial gain to be had by hybridization and both the Canadian and American Bison Associations share the goal of preserving pure bison herds.
However, at present, most private herds have yet to be tested for bovine DNA and the majority of Plains Bison in North America can be found in these private herds. As these herds have been built from the same original base stock as the public herds, is possible that up to 6% of some herds may contain bovine DNA. Consequently, out of approximately 500,000 Bison in North America, it is possible that up to 30,000 may have some bovine DNA. Fortunately, due to many base herds having started pure with feed stock from pure public herds such as Elk Island Park, this is a worst case figure and the true numbers of bison containing bovine DNA are likely to be significantly lower.
Yaks can also cross with bison; the hybrid offspring are occasionally kept by farmers in northern Alberta where the snowy, cold winters necessitate a cold-hardy animal.
In Tibet and Mongolia, yaks are quite often cross-bred to dairy cattle, the result being known as dzo or zho. The offspring are used as milk cows, if female, or as oxen of burden, if male.
Intraspecific Bos hybrids
Bos primigenius and longifrons have been ranked by nearly all palaeontologists as distinct species; and it would not be reasonable to take a different view simply because their domesticated descendants now intercross with the utmost freedom. All the European breeds have so often been crossed both intentionally and unintentionally, that, if any sterility had ensued from such unions, it would certainly have been detected. [...] The late Lord Powis imported some zebus and crossed them with common cattle in Shropshire; and I was assured by his steward that the cross-bred animals were perfectly fertile with both parent-stocks. Mr. Blyth informs me that in India hybrids, with various proportions of either blood, are quite fertile; and [...] are allowed to breed freely together.
The zebu, now called Bos taurus indicus, is the common domestic cow in much of Asia. They have been interbred with other domestic cattle over thousands of years. Some zebu breeds are derived from hybrids between zebu and yak, gaur and banteng. Zebu breeds have been widely crossed with European cattle. In Brazil, the Chanchim breed is 5/8 Charolais and 3/8 Zebu and combines the Charolais' meat quality and yield with the zebu's heat-resistance.
In India, Nepal, Tibet, and Mongolia, cattle are crossbred with yaks. This gives rise to the infertile male Dzo as well as fertile females which are bred into cattle breeds. The "Dwarf Lulu" breed of cattle was tested for DNA markers and found to be a mixture of both types of cattle with yak genetics.
Water buffalo/Domestic cattle hybrids
Intra-specific bison hybrids
A herd of hybrid plains bison x wood bison lived wild in the Yukon, Canada. The Wood bison is a distinct subspecies that almost became extinct in the 20th century. In an attempt to save the Plains bison subspecies, between 1925 and 1928, thousands of Plains bison were released into Wood Buffalo Park (a preserve for the Wood bison subspecies). They readily interbred and produced a 12,000 strong herd by 1934. The Wood bison was nearly hybridized into extinction. A small genetically pure herd was recovered from an isolated area in 1959 and is now being kept isolated from introduced Plains bison. Unfortunately, recent genetic testing seems to indicate that these supposedly pure wood bison are also hybridized with the plains subspecies, though the majority of the genetic makeup is that of the 'Wood Buffalo.'
The jumart is an alleged cattle-horse hybrid. Numerous early French scientists and veterinarians believed in their existence and one handbook on animal husbandry even included illustrated instructions on how to produce one. The claims are little-known (and considered to be mythical) elsewhere in the world. Horses belong to a different order (perissodactyls) from bovines, not merely a different family. 
- African buffalo
- American Bison Society
- American bison (Bison bison)
- Antelope Island Bison Herd
- Bison antiquus
- Bison bonasus
- Bison latifrons (Giant bison) (Longhorn Bison)
- Bison occidentalis
- Bison priscus
- Bison hunting
- European bison
- Henry Mountains Bison Herd
- Steppe Bison
- Water Buffalo
- Wood bison
- Yellowstone Park Bison Herd
- Mitochondrial DNA analysis of Nepalese domestic dwarf cattle Lulu, http://www.ingentaconnect.com/content/bsc/asj/2004/00000075/00000002/art00003, TAKEDA K.; SATOH M.1; NEOPANE S.P.2; KUWAR B.S.2; JOSHI H.D.2; SHRESTHA N.P.2; FUJISE H.3; TASAI M.4; TAGAMI T.4; HANADA H., Animal Science Journal, Volume 75, Number 2, April 2004, pp. 103-110(8)
- Patil, Shekhar, and Satish Totey. 2003. “Developmental Failure of Hybrid Embryos Generated by in Vitro Fertilization of Water Buffalo (Bubalus Bubalis) Oocyte with Bovine Spermatozoa.” Molecular Reproduction and Development 64 (3):360–68. https://doi.org/10.1002/mrd.10269.