CTU2

CTU2
Identifiers
Aliases	CTU2, C16orf84, NCS2, UPF0432, cytosolic thiouridylase subunit 2, MFRG
External IDs	OMIM: 617057; MGI: 1914215; HomoloGene: 79815; GeneCards: CTU2; OMA:CTU2 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	88,715,396 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	123,210,877 bp
RNA expression pattern
	Top expressed in
	oocyte; ; gonad; ; muscle of thigh; ; gastrocnemius muscle; ; left uterine tube; ; prefrontal cortex; ; apex of heart; ; right frontal lobe; ; Brodmann area 9; ; cingulate gyrus;
	Top expressed in
	otic vesicle; ; Paneth cell; ; fossa; ; medullary collecting duct; ; condyle; ; Rostral migratory stream; ; trigeminal ganglion; ; renal corpuscle; ; internal carotid artery; ; hair follicle;
	More reference expression data
	n/a
Gene ontology
Molecular function	tRNA binding; protein binding; sulfurtransferase activity; nucleotidyltransferase activity;
Cellular component	cytoplasm; cytosol; protein-containing complex;
Biological process	tRNA wobble uridine modification; tRNA thio-modification; tRNA processing; tRNA wobble position uridine thiolation; protein urmylation; tRNA modification;
	Sources:Amigo / QuickGO
Orthologs
	348180
	66965
	ENSG00000174177
	ENSMUSG00000049482
	Q2VPK5
	Q3U308
	NM_001012759; NM_001012762; NM_001318507; NM_001318513
	NM_153775
	NP_001012777; NP_001012780; NP_001305436; NP_001305442
	NP_722470
	Wikidata
View/Edit Human	View/Edit Mouse

CTU2 (formerly known as C16orf84) is a human gene located on chromosome 16.^[5] The mRNA encodes the longer isoform. The gene encodes a cytoplasmic protein that plays a probable role in tRNA modification.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000174177 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049482 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: C16orf84".
^ "NCBI protein: cytoplasmic tRNA 2-thiolation protein 2 isoform 1".

External links

Human CTU2 genome location and CTU2 gene details page in the UCSC Genome Browser.

Schlieker CD, Van der Veen AG, Damon JR, Spooner E, Ploegh HL (November 2008). "A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway". Proc. Natl. Acad. Sci. U.S.A. 105 (47): 18255–60. doi:10.1073/pnas.0808756105. PMC 2584574. PMID 19017811.
Dephoure N, Zhou C, Villén J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP (August 2008). "A quantitative atlas of mitotic phosphorylation". Proc. Natl. Acad. Sci. U.S.A. 105 (31): 10762–7. doi:10.1073/pnas.0805139105. PMC 2504835. PMID 18669648.

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000174177 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049482 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: C16orf84".

[PubMed-6] "NCBI protein: cytoplasmic tRNA 2-thiolation protein 2 isoform 1".

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References

External links

Further reading