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Aliases CABYR, CABYRa, CABYRc, CABYRc/d, CABYRe, CBP86, CT88, FSP-2, FSP2, calcium binding tyrosine phosphorylation regulated
External IDs MGI: 1918382 HomoloGene: 49299 GeneCards: CABYR
Gene location (Human)
Chromosome 18 (human)
Chr. Chromosome 18 (human)[1]
Chromosome 18 (human)
Genomic location for CABYR
Genomic location for CABYR
Band 18q11.2 Start 24,138,956 bp[1]
End 24,161,603 bp[1]
RNA expression pattern
PBB GE CABYR 219928 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC) Chr 18: 24.14 – 24.16 Mb Chr 18: 12.74 – 12.76 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Calcium-binding tyrosine phosphorylation-regulated protein is a protein that in humans is encoded by the CABYR gene.[5][6][7][8]

To reach fertilization competence, spermatozoa undergo a series of morphological and molecular maturational processes, termed capacitation, involving protein tyrosine phosphorylation and increased intracellular calcium. The protein encoded by this gene localizes to the principal piece of the sperm flagellum in association with the fibrous sheath and exhibits calcium-binding when phosphorylated during capacitation. A pseudogene on chromosome 3 has been identified for this gene. Transcript variants of this gene encode multiple protein isoforms. An additional transcript and isoform has not been fully characterized.[8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000154040 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024430 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Naaby-Hansen S, Mandal A, Wolkowicz MJ, Sen B, Westbrook VA, Shetty J, Coonrod SA, Klotz KL, Kim YH, Bush LA, Flickinger CJ, Herr JC (Jan 2002). "CABYR, a novel calcium-binding tyrosine phosphorylation-regulated fibrous sheath protein involved in capacitation". Dev Biol. 242 (2): 236–54. doi:10.1006/dbio.2001.0527. PMID 11820818. 
  6. ^ Luo C, Xiao X, Liu D, Chen S, Li M, Xu A, Liu J, Gao S, Wu S, He D (Feb 2007). "CABYR is a novel cancer-testis antigen in lung cancer". Clin Cancer Res. 13 (4): 1288–97. doi:10.1158/1078-0432.CCR-06-1742. PMID 17317841. 
  7. ^ Kim YH, Jha KN, Mandal A, Vanage G, Farris E, Snow PL, Klotz K, Naaby-Hansen S, Flickinger CJ, Herr JC (Oct 2005). "Translation and assembly of CABYR coding region B in fibrous sheath and restriction of calcium binding to coding region A". Dev Biol. 286 (1): 46–56. doi:10.1016/j.ydbio.2005.07.005. PMID 16139264. 
  8. ^ a b "Entrez Gene: CABYR calcium binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)". 

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