CADPS

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CADPS
Protein CADPS PDB 1wi1.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCADPS, CADPS1, CAPS, CAPS1, UNC-31, Ca2+ dependent secretion activator, calcium dependent secretion activator
External IDsOMIM: 604667 MGI: 1350922 HomoloGene: 2755 GeneCards: CADPS
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for CADPS
Genomic location for CADPS
Band3p14.2Start62,398,346 bp[1]
End62,875,416 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003716
NM_183393
NM_183394

NM_001042617
NM_012061
NM_001359919
NM_001359920
NM_001359921

RefSeq (protein)

NP_003707
NP_899630
NP_899631

NP_001036082
NP_036191
NP_001346848
NP_001346849
NP_001346850

Location (UCSC)Chr 3: 62.4 – 62.88 MbChr 14: 12.37 – 12.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Calcium-dependent secretion activator 1 is a protein that in humans is encoded by the CADPS gene.[5][6]

CADPS encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. CADPS acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163618 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054423 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Walent JH, Porter BW, Martin TF (Oct 1992). "A novel 145 kd brain cytosolic protein reconstitutes Ca(2+)-regulated secretion in permeable neuroendocrine cells". Cell. 70 (5): 765–75. doi:10.1016/0092-8674(92)90310-9. PMID 1516133.
  6. ^ a b "Entrez Gene: CADPS Ca2+-dependent secretion activator".

External links[edit]

Further reading[edit]