CALML5

CALML5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2B1U
Identifiers
Aliases	CALML5, CLSP, calmodulin like 5
External IDs	OMIM: 605183; MGI: 1931464; HomoloGene: 49485; GeneCards: CALML5; OMA:CALML5 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10p15.1 Start 5,498,697 bp End 5,499,570 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13|13 A1 Start 3,887,757 bp End 3,888,673 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen vulva skin of leg human penis skin of thigh skin of hip skin of arm nipple minor salivary glands parotid gland Top expressed in lip skin of external ear esophagus umbilical cord skin of abdomen superior surface of tongue skin of back condyle fossa molar More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding calcium ion binding enzyme regulator activity Cellular component extracellular region ficolin-1-rich granule lumen nucleus Biological process signal transduction epidermis development neutrophil degranulation calcium-mediated signaling regulation of catalytic activity spindle pole body organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51806 80796 Ensembl ENSG00000178372 ENSMUSG00000033765 UniProt Q9NZT1 Q9JM83 RefSeq (mRNA) NM_017422 NM_020036 RefSeq (protein) NP_059118 NP_064420 Location (UCSC) Chr 10: 5.5 – 5.5 Mb Chr 13: 3.89 – 3.89 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Calmodulin-like protein 5 is a protein that in humans is encoded by the CALML5 gene.

This gene encodes a novel calcium binding protein expressed in the epidermis and related to the calmodulin family of calcium binding proteins. Functional studies with recombinant protein demonstrate it does bind calcium and undergoes a conformational change when it does so. Abundant expression is detected only in reconstructed epidermis and is restricted to differentiating keratinocytes. In addition, it can associate with transglutaminase 3, shown to be a key enzyme in the terminal differentiation of keratinocytes.

External links

• Human CALML5 genome location and CALML5 gene details page in the UCSC Genome Browser.
• Overview of all the structural information available in the PDB for UniProt: Q9NZT1 (Human Calmodulin-like protein 5) at the PDBe-KB.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Méhul B, Bernard D, Schmidt R (2001). "Calmodulin-like skin protein: a new marker of keratinocyte differentiation". J. Invest. Dermatol. 116 (6): 905–9. doi:10.1046/j.0022-202x.2001.01376.x. PMID 11407979.
• Durussel I, Méhul B, Bernard D, et al. (2002). "Cation- and peptide-binding properties of human calmodulin-like skin protein". Biochemistry. 41 (17): 5439–48. doi:10.1021/bi016062z. PMID 11969404.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Méhul B, Bernard D, Brouard M, et al. (2006). "Influence of calcium on the proteolytic degradation of the calmodulin-like skin protein (calmodulin-like protein 5) in psoriatic epidermis". Exp. Dermatol. 15 (6): 469–77. doi:10.1111/j.1600-0625.2006.00433.x. PMID 16689864. S2CID 32717375.
• Babini E, Bertini I, Capozzi F, et al. (2006). "A structural and dynamic characterization of the EF-hand protein CLSP". Structure. 14 (6): 1029–38. doi:10.1016/j.str.2006.04.004. PMID 16765896.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.