CCNC (gene)

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Available structures
PDB Ortholog search: PDBe RCSB
Aliases CCNC, CycC, cyclin C, hSRB11, SRB11
External IDs MGI: 1858199 HomoloGene: 3803 GeneCards: CCNC
RNA expression pattern
PBB GE CCNC 201955 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)


Location (UCSC) Chr 6: 99.54 – 99.57 Mb Chr 4: 21.73 – 21.76 Mb
PubMed search [1] [2]
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Cyclin-C is a protein that in humans is encoded by the CCNC gene.[3][4]

The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phosphorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene.[4]


CCNC (gene) has been shown to interact with Estrogen receptor alpha[5] and Cyclin-dependent kinase 8.[5][6][7][8][9]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Lew DJ, Dulic V, Reed SI (Oct 1991). "Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast". Cell. 66 (6): 1197–206. doi:10.1016/0092-8674(91)90042-W. PMID 1833066. 
  4. ^ a b "Entrez Gene: CCNC cyclin C". 
  5. ^ a b Kang, Yun Kyoung; Guermah Mohamed; Yuan Chao-Xing; Roeder Robert G (Mar 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors α and β through the TRAP220 subunit and directly enhances estrogen receptor function in vitro". Proc. Natl. Acad. Sci. U.S.A. United States. 99 (5): 2642–7. doi:10.1073/pnas.261715899. ISSN 0027-8424. PMC 122401Freely accessible. PMID 11867769. 
  6. ^ Zhang, Y; Iratni R; Erdjument-Bromage H; Tempst P; Reinberg D (May 1997). "Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex". Cell. UNITED STATES. 89 (3): 357–64. doi:10.1016/S0092-8674(00)80216-0. ISSN 0092-8674. PMID 9150135. 
  7. ^ Cho, H; Orphanides G; Sun X; Yang X J; Ogryzko V; Lees E; Nakatani Y; Reinberg D (Sep 1998). "A Human RNA Polymerase II Complex Containing Factors That Modify Chromatin Structure". Mol. Cell. Biol. UNITED STATES. 18 (9): 5355–63. ISSN 0270-7306. PMC 109120Freely accessible. PMID 9710619. 
  8. ^ Wang, G; Cantin G T; Stevens J L; Berk A J (Jul 2001). "Characterization of Mediator Complexes from HeLa Cell Nuclear Extract". Mol. Cell. Biol. United States. 21 (14): 4604–13. doi:10.1128/MCB.21.14.4604-4613.2001. ISSN 0270-7306. PMC 87123Freely accessible. PMID 11416138. 
  9. ^ Tassan, J P; Jaquenoud M; Léopold P; Schultz S J; Nigg E A (Sep 1995). "Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C". Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 92 (19): 8871–5. doi:10.1073/pnas.92.19.8871. ISSN 0027-8424. PMC 41069Freely accessible. PMID 7568034. 

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