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Protein CD300LF PDB 2nms.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesCD300LF, CD300f, CLM-1, CLM1, IREM-1, IREM1, IgSF13, LMIR3, NKIR, CD300 molecule like family member f
External IDsMGI: 2442359 HomoloGene: 51396 GeneCards: CD300LF
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for CD300LF
Genomic location for CD300LF
Band17q25.1Start74,694,311 bp[1]
End74,712,978 bp[1]
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC)Chr 17: 74.69 – 74.71 MbChr 11: 115.12 – 115.13 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

CMRF35-like molecule 1 is a protein that in humans is encoded by the CD300LF gene.[5][6]

CD300LF is an inhibitory receptor of the Ig superfamily expressed on myeloid cells. It mediates negative regulatory signals by recruiting SHP1 (PTPN6; MIM 176883) or SHIP (INPP5D; MIM 601582) (Sui et al., 2004; Alvarez-Errico et al., 2004).[supplied by OMIM][6]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186074 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000047798 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  6. ^ a b "Entrez Gene: CD300LF CD300 molecule-like family member f".

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