CD300lf has been shown to function as the primary receptor for murine norovirus in mice, Human norovirus does not use the same receptor in viral entry. Human and murine CD300lf proteins have about 59% identity in their immunoglobulin domains, with most of that variation occurring in parts of the protein called CDR3 and the CC’loop. Murine norovirus binds to a cleft between these domains. The differences between murine and human CD300lf contribute to murine norovirushost species restriction, as incorporating murine CD300lf into human cells makes them susceptible to infection by the murine virus.
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