CD300lf has been shown to function as the primary receptor for murine norovirus in mice, but it's still unknown whether human norovirus uses the same receptor in viral entry or not. Human and murine CD300lf proteins have about 59% identity in their immunoglobulin domains, with most of that variation occurring in parts of the protein called CDR3 and the CC’loop. Murine norovirus binds to a cleft between these domains. The differences between murine and human CD300lf contribute to murine norovirushost species restriction, as incorporating murine CD300lf into human cells makes them susceptible to infection by the murine virus.
^Márquez JA, Galfré E, Dupeux F, Flot D, Moran O, Dimasi N (March 2007). "The crystal structure of the extracellular domain of the inhibitor receptor expressed on myeloid cells IREM-1". Journal of Molecular Biology. 367 (2): 310–8. doi:10.1016/j.jmb.2007.01.011. PMID17275839.
Sui L, Li N, Liu Q, Zhang W, Wan T, Wang B, Luo K, Sun H, Cao X (July 2004). "IgSF13, a novel human inhibitory receptor of the immunoglobulin superfamily, is preferentially expressed in dendritic cells and monocytes". Biochemical and Biophysical Research Communications. 319 (3): 920–8. doi:10.1016/j.bbrc.2004.05.065. PMID15184070.
Alvarez-Errico D, Aguilar H, Kitzig F, Brckalo T, Sayós J, López-Botet M (December 2004). "IREM-1 is a novel inhibitory receptor expressed by myeloid cells". European Journal of Immunology. 34 (12): 3690–701. doi:10.1002/eji.200425433. PMID15549731.
Alvarez-Errico D, Sayós J, López-Botet M (January 2007). "The IREM-1 (CD300f) inhibitory receptor associates with the p85alpha subunit of phosphoinositide 3-kinase". Journal of Immunology. 178 (2): 808–16. doi:10.4049/jimmunol.178.2.808. PMID17202342.