CILP

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CILP
Identifiers
Aliases CILP, CILP-1, HsT18872, cartilage intermediate layer protein
External IDs MGI: 2444507 HomoloGene: 2679 GeneCards: CILP
RNA expression pattern
PBB GE CILP 206227 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003613

NM_173385

RefSeq (protein)

NP_003604

NP_775561.1
NP_775561

Location (UCSC) Chr 15: 65.19 – 65.21 Mb Chr 9: 65.27 – 65.28 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Cartilage intermediate layer protein 1 is a protein that in humans is encoded by the CILP gene.[3][4][5]

Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. The synthesis of cartilage intermediate layer protein (CILP), which was identified and purified from human articular cartilage, increases in early osteoarthrosis cartilage. The C-terminal 460 amino acids of the protein show 90% similarity to the pig ectonucleotide pyrophosphohydrolase NTPPHase; this region is preceded by a furin protease consensus cleavage site. Thus, the CILP gene is thought to encode a protein precursor for 2 different proteins, namely CILP and a homolog of NTPPHase.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Lorenzo P, Neame P, Sommarin Y, Heinegard D (Oct 1998). "Cloning and deduced amino acid sequence of a novel cartilage protein (CILP) identifies a proform including a nucleotide pyrophosphohydrolase". J Biol Chem. 273 (36): 23469–75. doi:10.1074/jbc.273.36.23469. PMID 9722584. 
  4. ^ Lorenzo P, Bayliss MT, Heinegard D (Oct 1998). "A novel cartilage protein (CILP) present in the mid-zone of human articular cartilage increases with age". J Biol Chem. 273 (36): 23463–8. doi:10.1074/jbc.273.36.23463. PMID 9722583. 
  5. ^ a b "Entrez Gene: CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase". 

External links[edit]

Further reading[edit]