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CILP

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CILP
Identifiers
AliasesCILP, CILP-1, HsT18872, cartilage intermediate layer protein
External IDsOMIM: 603489; MGI: 2444507; HomoloGene: 2679; GeneCards: CILP; OMA:CILP - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003613

NM_173385
NM_001364527

RefSeq (protein)

NP_003604

NP_775561
NP_001351456

Location (UCSC)Chr 15: 65.19 – 65.21 MbChr 9: 65.17 – 65.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cartilage intermediate layer protein 1 is a protein that in humans is encoded by the CILP gene.[5][6][7]

Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. The synthesis of cartilage intermediate layer protein (CILP), which was identified and purified from human articular cartilage, increases in early osteoarthrosis cartilage. The C-terminal 460 amino acids of the protein show 90% similarity to the pig ectonucleotide pyrophosphohydrolase NTPPHase; this region is preceded by a furin protease consensus cleavage site. Thus, the CILP gene is thought to encode a protein precursor for 2 different proteins, namely CILP and a homolog of NTPPHase.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138615Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042254Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lorenzo P, Neame P, Sommarin Y, Heinegard D (Oct 1998). "Cloning and deduced amino acid sequence of a novel cartilage protein (CILP) identifies a proform including a nucleotide pyrophosphohydrolase". J Biol Chem. 273 (36): 23469–75. doi:10.1074/jbc.273.36.23469. PMID 9722584.
  6. ^ Lorenzo P, Bayliss MT, Heinegard D (Oct 1998). "A novel cartilage protein (CILP) present in the mid-zone of human articular cartilage increases with age". J Biol Chem. 273 (36): 23463–8. doi:10.1074/jbc.273.36.23463. PMID 9722583.
  7. ^ a b "Entrez Gene: CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase".
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Further reading

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