CLDN5

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CLDN5
Identifiers
Aliases CLDN5, AWAL, BEC1, CPETRL1, TMVCF, claudin 5, TMDVCF
External IDs MGI: 1276112 HomoloGene: 2459 GeneCards: CLDN5
Gene location (Human)
Chromosome 22 (human)
Chr. Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for CLDN5
Genomic location for CLDN5
Band 22q11.21 Start 19,523,024 bp[1]
End 19,527,545 bp[1]
RNA expression pattern
PBB GE CLDN5 204482 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003277
NM_001130861
NM_001363066
NM_001363067

NM_013805

RefSeq (protein)

NP_001124333
NP_003268
NP_001349995
NP_001349996

NP_038833

Location (UCSC) Chr 22: 19.52 – 19.53 Mb Chr 16: 18.78 – 18.78 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Claudin-5 is a protein that in humans is encoded by the CLDN5 gene.[5][6][7] It belongs to the group of claudins.

Function[edit]

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome.[7]

Interactions[edit]

CLDN5 has been shown to interact with CLDN1[8] and CLDN3.[8]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000184113 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041378 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Peacock RE, Keen TJ, Inglehearn CF (December 1997). "Analysis of a human gene homologous to rat ventral prostate.1 protein". Genomics. 46 (3): 443–9. doi:10.1006/geno.1997.5033. PMID 9441748. 
  6. ^ Sirotkin H, Morrow B, Saint-Jore B, Puech A, Das Gupta R, Patanjali SR, Skoultchi A, Weissman SM, Kucherlapati R (Sep 1997). "Identification, characterization, and precise mapping of a human gene encoding a novel membrane-spanning protein from the 22q11 region deleted in velo-cardio-facial syndrome". Genomics. 42 (2): 245–51. doi:10.1006/geno.1997.4734. PMID 9192844. 
  7. ^ a b "Entrez Gene: CLDN5 claudin 5 (transmembrane protein deleted in velocardiofacial syndrome)". 
  8. ^ a b Coyne CB, Gambling TM, Boucher RC, Carson JL, Johnson LG (Nov 2003). "Role of claudin interactions in airway tight junctional permeability". Am. J. Physiol. Lung Cell Mol. Physiol. 285 (5): L1166–78. doi:10.1152/ajplung.00182.2003. PMID 12909588. 

External links[edit]

Further reading[edit]