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Claudin 5
External IDs OMIM602101 MGI1276112 HomoloGene2459 GeneCards: CLDN5 Gene
RNA expression pattern
PBB GE CLDN5 204482 at tn.png
More reference expression data
Species Human Mouse
Entrez 7122 12741
Ensembl ENSG00000184113 ENSMUSG00000041378
UniProt O00501 O54942
RefSeq (mRNA) NM_001130861 NM_013805
RefSeq (protein) NP_001124333 NP_038833
Location (UCSC) Chr 22:
19.51 – 19.52 Mb
Chr 16:
18.78 – 18.78 Mb
PubMed search [1] [2]

Claudin-5 is a protein that in humans is encoded by the CLDN5 gene.[1][2][3] It belongs to the group of claudins.


This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome.[3]


CLDN5 has been shown to interact with CLDN1[4] and CLDN3.[4]


  1. ^ Peacock RE, Keen TJ, Inglehearn CF (Mar 1998). "Analysis of a human gene homologous to rat ventral prostate.1 protein". Genomics 46 (3): 443–9. doi:10.1006/geno.1997.5033. PMID 9441748.  Check date values in: |year= / |date= mismatch (help)
  2. ^ Sirotkin H, Morrow B, Saint-Jore B, Puech A, Das Gupta R, Patanjali SR et al. (Sep 1997). "Identification, characterization, and precise mapping of a human gene encoding a novel membrane-spanning protein from the 22q11 region deleted in velo-cardio-facial syndrome". Genomics 42 (2): 245–51. doi:10.1006/geno.1997.4734. PMID 9192844. 
  3. ^ a b "Entrez Gene: CLDN5 claudin 5 (transmembrane protein deleted in velocardiofacial syndrome)". 
  4. ^ a b Coyne CB, Gambling TM, Boucher RC, Carson JL, Johnson LG (Nov 2003). "Role of claudin interactions in airway tight junctional permeability". Am. J. Physiol. Lung Cell Mol. Physiol. 285 (5): L1166–78. doi:10.1152/ajplung.00182.2003. PMID 12909588. 

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