CLDN5

CLDN5
Identifiers
Aliases	CLDN5, AWAL, BEC1, CPETRL1, TMVCF, claudin 5, TMDVCF
External IDs	OMIM: 602101; MGI: 1276112; HomoloGene: 2459; GeneCards: CLDN5; OMA:CLDN5 - orthologs
Gene location (Human) Chr. Chromosome 22 (human) Band 22q11.21 Start 19,523,024 bp End 19,527,545 bp
Gene location (Mouse) Chr. Chromosome 16 (mouse) Band 16 A3|16 11.63 cM Start 18,595,597 bp End 18,597,012 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lung upper lobe of lung upper lobe of left lung pericardium lower lobe of lung subcutaneous adipose tissue C1 segment dorsal motor nucleus of vagus nerve inferior olivary nucleus olfactory bulb Top expressed in right lung right lung lobe left lung external carotid artery renal corpuscle internal carotid artery left lung lobe endothelial cell of lymphatic vessel lactiferous gland medial ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural molecule activity identical protein binding Cellular component membrane apicolateral plasma membrane cortical actin cytoskeleton cell-cell junction integral component of membrane bicellular tight junction plasma membrane cell junction Biological process cell-cell junction assembly transforming growth factor beta receptor signaling pathway outflow tract morphogenesis learning positive regulation of establishment of endothelial barrier roof of mouth development calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules face morphogenesis regulation of bicellular tight junction assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7122 12741 Ensembl ENSG00000184113 ENSMUSG00000041378 UniProt O00501 O54942 RefSeq (mRNA) NM_003277 NM_001130861 NM_001363066 NM_001363067 NM_013805 RefSeq (protein) NP_001124333 NP_003268 NP_001349995 NP_001349996 NP_038833 Location (UCSC) Chr 22: 19.52 – 19.53 Mb Chr 16: 18.6 – 18.6 Mb PubMed search
Wikidata
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Claudin-5 is a protein that in humans is encoded by the CLDN5 gene. It belongs to the group of claudins.

Function

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome.

Interactions

CLDN5 has been shown to interact with CLDN1 and CLDN3.

Further reading

• Kniesel U, Wolburg H (2000). "Tight junctions of the blood-brain barrier". Cell. Mol. Neurobiol. 20 (1): 57–76. doi:10.1023/A:1006995910836. PMID 10690502.
• Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2): 93–8. doi:10.1034/j.1600-0854.2001.020203.x. PMID 11247307.
• Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID 11283726.
• Tsukita S, Furuse M (2002). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): 531–6. doi:10.1016/S0955-0674(02)00362-9. PMID 12231346.
• González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins". Prog. Biophys. Mol. Biol. 81 (1): 1–44. doi:10.1016/S0079-6107(02)00037-8. PMID 12475568.
• King JE, Eugenin EA, Buckner CM, Berman JW (2006). "HIV tat and neurotoxicity". Microbes Infect. 8 (5): 1347–57. doi:10.1016/j.micinf.2005.11.014. PMID 16697675.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Morita K, Furuse M, Fujimoto K, Tsukita S (1999). "Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands". Proc. Natl. Acad. Sci. U.S.A. 96 (2): 511–6. doi:10.1073/pnas.96.2.511. PMC 15167. PMID 9892664.
• Itoh M, Furuse M, Morita K, Kubota K, Saitou M, Tsukita S (1999). "Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins". J. Cell Biol. 147 (6): 1351–63. doi:10.1083/jcb.147.6.1351. PMC 2168087. PMID 10601346.
• Kojima S, Rahner C, Peng S, Rizzolo LJ (2002). "Claudin 5 is transiently expressed during the development of the retinal pigment epithelium". J. Membr. Biol. 186 (2): 81–8. doi:10.1007/s00232-001-0137-7. PMID 11944085.
• Poliak S, Matlis S, Ullmer C, Scherer SS, Peles E (2002). "Distinct claudins and associated PDZ proteins form different autotypic tight junctions in myelinating Schwann cells". J. Cell Biol. 159 (2): 361–72. doi:10.1083/jcb.200207050. PMC 2173042. PMID 12403818.
• Helms HC, Waagepetersen HS, Nielsen CU, Brodin B (2010). "Paracellular tightness and claudin-5 expression is increased in the BCEC/astrocyte blood-brain barrier model by increasing media buffer capacity during growth". AAPS J. 12 (4): 759–70. doi:10.1208/s12248-010-9237-6. PMC 2976989. PMID 20967520.
• Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS (2015). "A systems proteomics view of the endogenous human claudin protein family". J Proteome Res. doi:10.1021/acs.jproteome.5b00769. PMID 26680015.