COG5

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COG5
Identifiers
Aliases COG5, CDG2I, GOLTC1, GTC90, component of oligomeric golgi complex 5
External IDs MGI: 2145130 HomoloGene: 42221 GeneCards: COG5
Genetically Related Diseases
osteoarthritis[1]
RNA expression pattern
PBB GE COG5 203630 s at fs.png

PBB GE COG5 203629 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001161520
NM_006348
NM_181733

NM_001163126

RefSeq (protein)

NP_001154992
NP_006339
NP_859422

NP_001156598.1
NP_001156598

Location (UCSC) Chr 7: 107.2 – 107.56 Mb Chr 12: 31.65 – 31.94 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Conserved oligomeric Golgi complex subunit 5 is a protein that in humans is encoded by the COG5 gene.[4][5][6]

Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex, which includes COG5 (Ungar et al., 2002).[supplied by OMIM][6]

Interactions[edit]

COG5 has been shown to interact with COG7[7] and COG4.[7]

References[edit]

  1. ^ "Diseases that are genetically associated with COG5 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Walter DM, Paul KS, Waters MG (Dec 1998). "Purification and characterization of a novel 13 S hetero-oligomeric protein complex that stimulates in vitro Golgi transport". J Biol Chem. 273 (45): 29565–76. doi:10.1074/jbc.273.45.29565. PMID 9792665. 
  5. ^ Ungar D, Oka T, Brittle EE, Vasile E, Lupashin VV, Chatterton JE, Heuser JE, Krieger M, Waters MG (Apr 2002). "Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function". J Cell Biol. 157 (3): 405–15. doi:10.1083/jcb.200202016. PMC 2173297Freely accessible. PMID 11980916. 
  6. ^ a b "Entrez Gene: COG5 component of oligomeric golgi complex 5". 
  7. ^ a b Loh, Eva; Hong Wanjin (Jun 2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex". J. Biol. Chem. United States. 279 (23): 24640–8. doi:10.1074/jbc.M400662200. ISSN 0021-9258. PMID 15047703. 

Further reading[edit]

External links[edit]