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Aliases COG5, CDG2I, GOLTC1, GTC90, component of oligomeric golgi complex 5
External IDs MGI: 2145130 HomoloGene: 42221 GeneCards: COG5
Gene location (Human)
Chromosome 7 (human)
Chr. Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for COG5
Genomic location for COG5
Band 7q22.3 Start 107,201,555 bp[1]
End 107,564,514 bp[1]
RNA expression pattern
PBB GE COG5 203630 s at fs.png

PBB GE COG5 203629 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 7: 107.2 – 107.56 Mb Chr 12: 31.65 – 31.94 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Conserved oligomeric Golgi complex subunit 5 is a protein that in humans is encoded by the COG5 gene.[5][6][7]

Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex, which includes COG5 (Ungar et al., 2002).[supplied by OMIM][7]


COG5 has been shown to interact with COG7[8] and COG4.[8]


  1. ^ a b c ENSG00000284369 GRCh38: Ensembl release 89: ENSG00000164597, ENSG00000284369 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035933 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Walter DM, Paul KS, Waters MG (Dec 1998). "Purification and characterization of a novel 13 S hetero-oligomeric protein complex that stimulates in vitro Golgi transport". J Biol Chem. 273 (45): 29565–76. doi:10.1074/jbc.273.45.29565. PMID 9792665. 
  6. ^ Ungar D, Oka T, Brittle EE, Vasile E, Lupashin VV, Chatterton JE, Heuser JE, Krieger M, Waters MG (Apr 2002). "Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function". J Cell Biol. 157 (3): 405–15. doi:10.1083/jcb.200202016. PMC 2173297Freely accessible. PMID 11980916. 
  7. ^ a b "Entrez Gene: COG5 component of oligomeric golgi complex 5". 
  8. ^ a b Loh, Eva; Hong Wanjin (Jun 2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex". J. Biol. Chem. United States. 279 (23): 24640–8. doi:10.1074/jbc.M400662200. ISSN 0021-9258. PMID 15047703. 

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