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Carboxypeptidase N, polypeptide 1
Protein CPN1 PDB 2nsm.png
PDB rendering based on 2nsm.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CPN1 ; CPN; SCPN
External IDs OMIM603103 MGI2135874 HomoloGene1002 ChEMBL: 4713 GeneCards: CPN1 Gene
EC number
RNA expression pattern
PBB GE CPN1 206256 at tn.png
More reference expression data
Species Human Mouse
Entrez 1369 93721
Ensembl ENSG00000120054 ENSMUSG00000025196
UniProt P15169 Q9JJN5
RefSeq (mRNA) NM_001308 NM_030703
RefSeq (protein) NP_001299 NP_109628
Location (UCSC) Chr 10:
100.04 – 100.08 Mb
Chr 19:
43.96 – 43.99 Mb
PubMed search [1] [2]

Carboxypeptidase N catalytic chain is an enzyme that in humans is encoded by the CPN1 gene.[1][2][3]

Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer composed of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency.[3]

In melanocytic cells CPN1 gene expression may be regulated by MITF.[4]


  1. ^ Riley DA, Tan F, Miletich DJ, Skidgel RA (Apr 1999). "Chromosomal localization of the genes for human carboxypeptidase D (CPD) and the active 50-kilodalton subunit of human carboxypeptidase N (CPN1)". Genomics 50 (1): 105–8. doi:10.1006/geno.1998.5295. PMID 9628828. 
  2. ^ Gebhard W, Schube M, Eulitz M (Mar 1989). "cDNA cloning and complete primary structure of the small, active subunit of human carboxypeptidase N (kininase 1)". Eur J Biochem 178 (3): 603–7. doi:10.1111/j.1432-1033.1989.tb14488.x. PMID 2912725. 
  3. ^ a b "Entrez Gene: CPN1 carboxypeptidase N, polypeptide 1". 
  4. ^ Hoek KS, Schlegel NC, Eichhoff OM; et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 

Further reading[edit]