From Wikipedia, the free encyclopedia
Jump to: navigation, search
Protein CPN1 PDB 2nsm.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases CPN1, CPN, SCPN, carboxypeptidase N subunit 1
External IDs MGI: 2135874 HomoloGene: 1002 GeneCards: 1369
RNA expression pattern
PBB GE CPN1 206256 at tn.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 10: 100.04 – 100.08 Mb Chr 19: 43.96 – 43.99 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Carboxypeptidase N catalytic chain is an enzyme that in humans is encoded by the CPN1 gene.[1][2][3]

Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer composed of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency.[3]

In melanocytic cells CPN1 gene expression may be regulated by MITF.[4]


  1. ^ Riley DA, Tan F, Miletich DJ, Skidgel RA (Apr 1999). "Chromosomal localization of the genes for human carboxypeptidase D (CPD) and the active 50-kilodalton subunit of human carboxypeptidase N (CPN1)". Genomics 50 (1): 105–8. doi:10.1006/geno.1998.5295. PMID 9628828. 
  2. ^ Gebhard W, Schube M, Eulitz M (Mar 1989). "cDNA cloning and complete primary structure of the small, active subunit of human carboxypeptidase N (kininase 1)". Eur J Biochem 178 (3): 603–7. doi:10.1111/j.1432-1033.1989.tb14488.x. PMID 2912725. 
  3. ^ a b "Entrez Gene: CPN1 carboxypeptidase N, polypeptide 1". 
  4. ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 

Further reading[edit]