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Aliases CRLF3, CREME-9, CREME9, CRLM9, CYTOR4, FRWS, p48.2, cytokine receptor like factor 3
External IDs MGI: 1860086 HomoloGene: 9327 GeneCards: CRLF3
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 17: 30.77 – 30.82 Mb Chr 11: 80.05 – 80.08 Mb
PubMed search [1] [2]
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Cytokine receptor-like factor 3 is a protein that in humans is encoded by the CRLF3 gene.[3]

Model organisms[edit]

Model organisms have been used in the study of CRLF3 function. A conditional knockout mouse line, called Crlf3tm1a(KOMP)Wtsi[10][11] was generated as part of the International Knockout Mouse Consortium program, a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[12][13][14] Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[8][15] Twenty six tests were carried out and two significant phenotypes were reported. Homozygous mutant female adults had a significant increase in circulating levels of fructosamine, while mutants of both sexes had decreased platelet cell numbers.[8]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ "Entrez Gene: cytokine receptor-like factor 3". 
  4. ^ "Clinical chemistry data for Crlf3". Wellcome Trust Sanger Institute. 
  5. ^ "Haematology data for Crlf3". Wellcome Trust Sanger Institute. 
  6. ^ "Salmonella infection data for Crlf3". Wellcome Trust Sanger Institute. 
  7. ^ "Citrobacter infection data for Crlf3". Wellcome Trust Sanger Institute. 
  8. ^ a b c Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x. 
  9. ^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  10. ^ "International Knockout Mouse Consortium". 
  11. ^ "Mouse Genome Informatics". 
  12. ^ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. PMC 3572410Freely accessible. PMID 21677750. doi:10.1038/nature10163. 
  13. ^ Dolgin E (June 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. PMID 21677718. doi:10.1038/474262a. 
  14. ^ Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. PMID 17218247. doi:10.1016/j.cell.2006.12.018. 
  15. ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol. 12 (6): 224. PMC 3218837Freely accessible. PMID 21722353. doi:10.1186/gb-2011-12-6-224. 

External links[edit]

Further reading[edit]