CSTF2

CSTF2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1P1T, 2J8P
Identifiers
Aliases	CSTF2, CstF-64, cleavage stimulation factor subunit 2
External IDs	OMIM: 300907; MGI: 1343054; HomoloGene: 80171; GeneCards: CSTF2; OMA:CSTF2 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	100,841,520 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	132,987,568 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; oral cavity; ; gonad; ; palpebral conjunctiva; ; mucosa of pharynx; ; testicle; ; ganglionic eminence; ; buccal mucosa cell; ; epithelium of nasopharynx;
	Top expressed in
	ventromedial nucleus; ; dorsomedial hypothalamic nucleus; ; paraventricular nucleus of hypothalamus; ; lateral hypothalamus; ; lateral septal nucleus; ; dorsal tegmental nucleus; ; anterior amygdaloid area; ; ventral tegmental area; ; arcuate nucleus; ; subiculum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleic acid binding; protein binding; mRNA binding; RNA binding;
Cellular component	mRNA cleavage and polyadenylation specificity factor complex; cleavage body; nucleoplasm; nucleus; nuclear body;
Biological process	mRNA splicing, via spliceosome; termination of RNA polymerase II transcription; mRNA processing; mRNA 3'-end processing; pre-mRNA cleavage required for polyadenylation; tRNA splicing, via endonucleolytic cleavage and ligation; mRNA polyadenylation;
	Sources:Amigo / QuickGO
Orthologs
	1478
	108062
	ENSG00000101811
	ENSMUSG00000031256
	P33240
	Q8BIQ5
	NM_001306206; NM_001306209; NM_001325
	NM_001290398; NM_001290399; NM_133196; NM_001359053; NM_001359054
	NP_001293135; NP_001293138; NP_001316; NP_001293135.1
	NP_001277327; NP_001277328; NP_573459; NP_001345982; NP_001345983
	Wikidata
View/Edit Human	View/Edit Mouse

Cleavage stimulation factor 64 kDa subunit is a protein that in humans is encoded by the CSTF2 gene.^[5]^[6]

Template:PBB Summary

Interactions

CSTF2 has been shown to interact with CSTF3,^[7] SUB1,^[8] SYMPK,^[7] BARD1^[9]^[10] and BRCA1.^[9]^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000101811 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031256 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Takagaki Y, MacDonald CC, Shenk T, Manley JL (March 1992). "The human 64-kDa polyadenylylation factor contains a ribonucleoprotein-type RNA binding domain and unusual auxiliary motifs". Proc Natl Acad Sci U S A. 89 (4): 1403–7. doi:10.1073/pnas.89.4.1403. PMC 48459. PMID 1741396.
^ "Entrez Gene: CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa".
^ ^a ^b Takagaki, Y; Manley J L (March 2000). "Complex protein interactions within the human polyadenylation machinery identify a novel component". Mol. Cell. Biol. 20 (5). UNITED STATES: 1515–25. doi:10.1128/MCB.20.5.1515-1525.2000. ISSN 0270-7306. PMC 85326. PMID 10669729. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help)
^ Calvo, O; Manley J L (May 2001). "Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination". Mol. Cell. 7 (5). United States: 1013–23. doi:10.1016/S1097-2765(01)00236-2. ISSN 1097-2765. PMID 11389848. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help)
^ ^a ^b Kleiman, F E; Manley J L (March 2001). "The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression". Cell. 104 (5). United States: 743–53. doi:10.1016/S0092-8674(01)00270-7. ISSN 0092-8674. PMID 11257228. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help)
^ ^a ^b Kleiman, F E; Manley J L (September 1999). "Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50". Science. 285 (5433). UNITED STATES: 1576–9. doi:10.1126/science.285.5433.1576. ISSN 0036-8075. PMID 10477523. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help)

Interactions

References

Further reading