CUL1

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CUL1
Protein CUL1 PDB 1ldj.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CUL1
External IDs MGI: 1349658 HomoloGene: 2663 GeneCards: CUL1
RNA expression pattern
PBB GE CUL1 207614 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003592

NM_012042

RefSeq (protein)

NP_003583

NP_036172.1
NP_036172

Location (UCSC) Chr 7: 148.7 – 148.8 Mb Chr 6: 47.45 – 47.53 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Cullin 1, also known as CUL1, is a human protein and gene from cullin family.

This protein plays an important role in protein degradation and protein ubiquitination.

This is an essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, it serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme.

This protein is a part of a SCF complex consisting of CUL1, RBX1, SKP1 and SKP2. It also interacts with RNF7. Part of a complex with TIP120A/CAND1 and RBX1. The unneddylated form interacts with TIP120A/CAND1 and the interaction negatively regulates the association with SKP1 in the SCF complex. Interacts with COPS2.

It is expressed in lung fibroblasts.

The protein is neddylated, which enhances the ubiquitination activity of SCF. Deneddylated via its interaction with the COP9 signalosome (CSN) complex.

Further reading[edit]



  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:".