Cadherin related family member 3

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
CDHR3
Identifiers
AliasesCDHR3, CDH28, cadherin related family member 3
External IDsOMIM: 615610 MGI: 1916014 HomoloGene: 45146 GeneCards: CDHR3
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for CDHR3
Genomic location for CDHR3
Band7q22.3Start105,876,796 bp[1]
End106,036,432 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001301161
NM_152750

NM_001024478

RefSeq (protein)

NP_001288090
NP_689963

NP_001019649

Location (UCSC)Chr 7: 105.88 – 106.04 MbChr 12: 33.03 – 33.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cadherin related family member 3 (CDHR3), also known as CDH28 or its abbreviation CDHR3, is a protein that in humans is encoded by the CDHR3 gene. [5] The protein is predominately expressed in respiratory epithelium[6] and the first notion of its clinical implications was from the discovery that genetic variation of CDHR3 is strongly associated to early severe asthma exacerbations in children.[7] Subsequent studies have suggested that CDHR3 is a receptor for a subtype of rhinovirus.[8][9]

Function and cellular location[edit]

The exact physiological role of CDHR3 is not known, but as the CDHR3 protein is expressed in epithelial tissues and has six extracellular cadherin domains plus a short transmembrane segment, it is believed to be related to the function of similar cadherins which function in cell adhesion and cell-to-cell signaling.[7] Two single-cell RNA expression studies furthermore found CDHR3 to be highly selectively expressed in ciliated epithelial cells, compared to other cell types in the respiratory epithelium, and thereby to be a marker for ciliated cells in respiratory airway tissue[10][11].

Clinical significance[edit]

A nonsynonymous mutation in CDHR3 at rs6967330 (C529Y) was at first found to be associated with severe asthma exacerbations in early childhood, with genome-wide significance. Functional experiments further indicated that this gene polymorphism leads to increased surface expression of the CDHR3 protein.[7] A subsequent study found that CDHR3 is a probable receptor for rhinovirus type C, a common form of rhinovirus.[8]

Recent studies furthermore found that CDHR3 gene variation is not associated with childhood bronchiolitis from respiratory syncytial virus (RSV) infection,[9] which resemble early asthma exacerbations as a phenotype. However, childhood bronchiolitis not caused by RSV infection, of which rhinovirus is often implicated, was associated with the CDHR3 gene variation. This is line with the results from a study on chronic rhinosinusitis, which often is associated rhinovirus infection, where CDHR3 gene variation also was found to be a strong risk factor.[12] Therefore, CDHR3 seems to causally linked to increased propensity for rhinovirus C infection.

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000128536 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035860 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Cadherin related family member 3". Retrieved 2017-09-05.
  6. ^ "Tissue expression of CDHR3 - Summary - The Human Protein Atlas". www.proteinatlas.org. Retrieved 2017-09-05.
  7. ^ a b c Bønnelykke K, Sleiman P, Nielsen K, Kreiner-Møller E, Mercader JM, Belgrave D, et al. (January 2014). "A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations". Nature Genetics. 46 (1): 51–5. doi:10.1038/ng.2830. PMID 24241537.
  8. ^ a b Bochkov YA, Watters K, Ashraf S, Griggs TF, Devries MK, Jackson DJ, et al. (April 2015). "Cadherin-related family member 3, a childhood asthma susceptibility gene product, mediates rhinovirus C binding and replication". Proceedings of the National Academy of Sciences of the United States of America. 112 (17): 5485–90. Bibcode:2015PNAS..112.5485B. doi:10.1073/pnas.1421178112. PMC 4418890. PMID 25848009.
  9. ^ a b Husby A, Pasanen A, Waage J, Sevelsted A, Hodemaekers H, Janssen R, et al. (November 2017). "CDHR3 gene variation and childhood bronchiolitis". The Journal of Allergy and Clinical Immunology. 140 (5): 1469–1471.e7. doi:10.1016/j.jaci.2017.06.044. PMC 5675819. PMID 28782631.
  10. ^ Montoro DT, Haber AL, Biton M, Vinarsky V, Lin B, Birket SE, et al. (August 2018). "A revised airway epithelial hierarchy includes CFTR-expressing ionocytes". Nature. 560 (7718): 319–324. doi:10.1038/s41586-018-0393-7. PMC 6295155. PMID 30069044.
  11. ^ Ordovas-Montanes J, Dwyer DF, Nyquist SK, Buchheit KM, Vukovic M, Deb C, et al. (August 2018). "Allergic inflammatory memory in human respiratory epithelial progenitor cells". Nature. 560 (7720): 649–654. doi:10.1038/s41586-018-0449-8. PMC 6133715. PMID 30135581.
  12. ^ Chang EH, Willis AL, McCrary HC, Noutsios GT, Le CH, Chiu AG, et al. (June 2017). "Association between the CDHR3 rs6967330 risk allele and chronic rhinosinusitis". The Journal of Allergy and Clinical Immunology. 139 (6): 1990–1992.e2. doi:10.1016/j.jaci.2016.10.027. PMC 5457723. PMID 27923563.

Further reading[edit]