Carboxylesterase 2

CES2
Identifiers
Aliases	CES2, CE-2, CES2A1, PCE-2, iCE, Carboxylesterase 2, CES-2
External IDs	OMIM: 605278; MGI: 3648740; HomoloGene: 128645; GeneCards: CES2; OMA:CES2 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	66,945,096 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	105,747,810 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; mucosa of ileum; ; mucosa of colon; ; mucosa of sigmoid colon; ; duodenum; ; mucosa of transverse colon; ; mucosa of pharynx; ; rectum; ; right lobe of liver; ; kidney tubule;
	Top expressed in
	proximal tubule; ; human kidney; ; right kidney; ; duodenum; ; jejunum; ; liver; ; colon; ; testicle; ; islet of Langerhans;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	methylumbelliferyl-acetate deacetylase activity; hydrolase activity; carboxylic ester hydrolase activity; methyl indole-3-acetate esterase activity;
Cellular component	endoplasmic reticulum lumen; endoplasmic reticulum; extracellular space;
Biological process	xenobiotic metabolic process; catabolic process; prostaglandin metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	8824
	436059
	ENSG00000172831
	ENSMUSG00000091813
	O00748
	F6Z9B9
NM_003869; NM_198061; NM_001365405; NM_001365406; NM_001365407;
	NM_001365408
	NM_001272045
NP_003860; NP_932327; NP_001352334; NP_001352335; NP_001352336;
	NP_001352337
	NP_001258974
	Wikidata
View/Edit Human	View/Edit Mouse

Carboxylesterase 2 is an enzyme that in humans is encoded by the CES2 gene.^[5]^[6]^[7] It is a member of the alpha/beta fold hydrolase family.^[8]

Template:PBB Summary

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

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|alt=Fluorouracil (5-FU) Activity edit]]

Fluorouracil (5-FU) Activity edit

^ The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

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|alt=Irinotecan Pathway edit]]

Irinotecan Pathway edit

^ The interactive pathway map can be edited at WikiPathways: "IrinotecanPathway_WP229".

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000172831 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000091813 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pindel EV, Kedishvili NY, Abraham TL, Brzezinski MR, Zhang J, Dean RA, Bosron WF (Jun 1997). "Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin". J Biol Chem. 272 (23): 14769–75. doi:10.1074/jbc.272.23.14769. PMID 9169443.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Schwer H, Langmann T, Daig R, Becker A, Aslanidis C, Schmitz G (Jun 1997). "Molecular cloning and characterization of a novel putative carboxylesterase, present in human intestine and liver". Biochem Biophys Res Commun. 233 (1): 117–20. doi:10.1006/bbrc.1997.6413. PMID 9144407.
^ "Entrez Gene: CES2 carboxylesterase 2 (intestine, liver)".
^ Imai T (Jun 2006). "Human Carboxylesterase Isozymes: Catalytic Properties and Rational Drug Design". Drug Metabolism and Pharmacokinetics. 21 (3): 173–185. doi:10.2133/dmpk.21.173. PMID 16858120.

Interactive pathway map

References

Further reading