Clyde Simmons, Jr. (born August 4, 1964) is a former American football defensive end in the National Football League who played for the Philadelphia Eagles (1986–1993), Arizona Cardinals (1994–1995), Jacksonville Jaguars (1996–1997), Cincinnati Bengals (1998), and the Chicago Bears (1999–2000). He was selected to the Pro Bowl in 1991 and 1992. He led the NFL with 19 sacks in 1992 and finished his career 11th all time on the NFL sack list, with 121.5.
Simmons returned an interception for a touchdown against Jim Kelly and the Buffalo Bills in the 1996 NFL Playoffs.
He graduated from Western Carolina University. He played in the 1983 National Championship game.
Simmons worked for a mortgage company and spent some time as a probation officer. In 2010, he accepted an offer from Rex Ryan as a fellowship coach with the New York Jets.