Cyclin dependent kinase like 1

CDKL1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4AGU
Identifiers
Aliases	CDKL1, KKIALRE, P42, cyclin dependent kinase like 1
External IDs	OMIM: 603441; MGI: 1918341; HomoloGene: 55805; GeneCards: CDKL1; OMA:CDKL1 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	50,416,461 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	69,838,041 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; Achilles tendon; ; canal of the cervix; ; body of uterus; ; ectocervix; ; epithelium of colon; ; muscle layer of sigmoid colon; ; right lobe of thyroid gland; ; left ovary; ; monocyte;
	Top expressed in
	right kidney; ; human kidney; ; lumbar subsegment of spinal cord; ; spermatid; ; spermatocyte; ; dentate gyrus of hippocampal formation granule cell; ; blood; ; visual cortex; ; primary visual cortex; ; superior frontal gyrus;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; ATP binding; kinase activity; cyclin-dependent protein serine/threonine kinase activity;
Cellular component	cytoplasm; extracellular exosome; nucleus; nucleoplasm; intracellular membrane-bounded organelle; ciliary transition zone;
Biological process	heart development; phosphorylation; regulation of cell cycle; protein phosphorylation; regulation of cilium assembly;
	Sources:Amigo / QuickGO
Orthologs
	8814
	71091
	ENSG00000100490
	ENSMUSG00000020990
	Q00532
	Q8CEQ0
	NM_001282236; NM_004196; NM_001367064; NM_001367065
	NM_183294
	NP_001269165; NP_004187; NP_001353993; NP_001353994
	NP_899117
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclin dependent kinase like 1 is a protein that in humans is encoded by the CDKL1 gene. ^[5]

Function

This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the nucleus. Two transcript variants encoding different isoforms have been found for this gene.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100490 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020990 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Cyclin dependent kinase like 1". Retrieved 2016-06-07.

Function

References

Further reading