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DENR (gene)

From Wikipedia, the free encyclopedia
DENR
Identifiers
AliasesDENR, DRP, DRP1, SMAP-3, density-regulated protein, density regulated re-initiation and release factor
External IDsOMIM: 604550; MGI: 1915434; HomoloGene: 6275; GeneCards: DENR; OMA:DENR - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003677

NM_026603

RefSeq (protein)

NP_003668

NP_080879

Location (UCSC)Chr 12: 122.75 – 122.77 MbChr 5: 124.05 – 124.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Density regulated re-initiation and release factor (DENR) is a protein that in humans is encoded by the DENR gene. [5]

Function

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This gene encodes a protein whose expression was found to increase in cultured cells at high density but not during growth arrest. This gene was also shown to have increased expression in cells overexpressing the HER2/neu proto-oncogene. The protein contains an SUI1 domain. In budding yeast, SUI1 is a translation initiation factor that along with eIF2 and the initiator Met-tRNAiMet, directs the ribosome to the proper translation start site. Proteins similar to SUI have been found in mammals, insects, and plants. [provided by RefSeq, Jul 2008].

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000139726Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023106Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Density regulated re-initiation and release factor". Retrieved 2018-01-17.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.