DGKZ

DGKZ
Identifiers
Aliases	DGKZ, DAGK5, DAGK6, DGK-ZETA, hDGKzeta, diacylglycerol kinase zeta
External IDs	OMIM: 601441; MGI: 1278339; HomoloGene: 37831; GeneCards: DGKZ; OMA:DGKZ - orthologs
EC number	2.7.1.107
Gene location (Human)
Chr.	Chromosome 11 (human)
End	46,380,554 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	91,806,209 bp
RNA expression pattern
	Top expressed in
	right frontal lobe; ; cingulate gyrus; ; anterior cingulate cortex; ; granulocyte; ; Brodmann area 9; ; apex of heart; ; gastrocnemius muscle; ; right hemisphere of cerebellum; ; muscle of thigh; ; anterior pituitary;
	Top expressed in
	lobe of cerebellum; ; cerebellar vermis; ; primary motor cortex; ; internal carotid artery; ; cingulate gyrus; ; prefrontal cortex; ; Paneth cell; ; subdivision of hippocampus; ; Region I of hippocampus proper; ; temporal lobe;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; lipid kinase activity; metal ion binding; protein C-terminus binding; protein binding; ATP binding; kinase activity; diacylglycerol kinase activity; NAD+ kinase activity;
Cellular component	membrane; plasma membrane; nucleus; lamellipodium; cytoplasm; nuclear speck; postsynaptic density; glutamatergic synapse; cell projection;
Biological process	intracellular signal transduction; platelet activation; protein kinase C-activating G protein-coupled receptor signaling pathway; mitotic G1 DNA damage checkpoint signaling; cell migration; negative regulation of mitotic cell cycle; glycerolipid metabolic process; phosphorylation; diacylglycerol metabolic process; lipid phosphorylation; metabolism; signal transduction; phosphatidic acid biosynthetic process; positive regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	8525
	104418
	ENSG00000149091
	ENSMUSG00000040479
	Q13574
	Q80UP3
NM_001105540; NM_001199266; NM_001199267; NM_001199268; NM_003646;
	NM_201532; NM_201533
	NM_001166597; NM_138306
NP_001099010; NP_001186195; NP_001186196; NP_001186197; NP_003637;
	NP_963290; NP_963291
	NP_001160069; NP_612179
	Wikidata
View/Edit Human	View/Edit Mouse

Diacylglycerol kinase zeta is an enzyme that in humans is encoded by the DGKZ gene.^[5]^[6]

Template:PBB Summary

Interactions

DGKZ has been shown to interact with P110α.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000149091 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040479 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bunting M, Tang W, Zimmerman GA, McIntyre TM, Prescott SM (Jun 1996). "Molecular cloning and characterization of a novel human diacylglycerol kinase zeta". J Biol Chem. 271 (17): 10230–6. doi:10.1074/jbc.271.17.10230. PMID 8626588.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ "Entrez Gene: DGKZ diacylglycerol kinase, zeta 104kDa".
^ Luo, Bai; Prescott Stephen M; Topham Matthew K (Oct 2003). "Protein kinase C alpha phosphorylates and negatively regulates diacylglycerol kinase zeta". J. Biol. Chem. 278 (41). United States: 39542–7. doi:10.1074/jbc.M307153200. ISSN 0021-9258. PMID 12890670. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help)CS1 maint: unflagged free DOI (link)

Interactions

References

Further reading