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Available structures
PDB Ortholog search: PDBe RCSB
Aliases DMAP1, DNMAP1, DNMTAP1, EAF2, MEAF2, SWC4, DNA methyltransferase 1 associated protein 1
External IDs MGI: 1913483 HomoloGene: 41311 GeneCards: DMAP1
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 1: 44.21 – 44.22 Mb Chr 4: 117.67 – 117.68 Mb
PubMed search [1] [2]
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DNA methyltransferase 1-associated protein 1 is an enzyme that in humans is encoded by the DMAP1 gene.[3][4][5]


This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described.[5]


DMAP1 has been shown to interact with:


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Rountree MR, Bachman KE, Baylin SB (Aug 2000). "DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci". Nat Genet. 25 (3): 269–77. doi:10.1038/77023. PMID 10888872. 
  4. ^ Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (Apr 2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198. 
  5. ^ a b "Entrez Gene: DMAP1 DNA methyltransferase 1 associated protein 1". 
  6. ^ Delgermaa L, Hayashi N, Dorjsuren D, Nomura T, Thuy le TT, Murakami S (Oct 2004). "Subcellular localization of RPB5-mediating protein and its putative functional partner". Mol. Cell. Biol. 24 (19): 8556–66. doi:10.1128/MCB.24.19.8556-8566.2004. PMC 516735Freely accessible. PMID 15367675. 
  7. ^ Rountree MR, Bachman KE, Baylin SB (Jul 2000). "DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci". Nat. Genet. 25 (3): 269–77. doi:10.1038/77023. PMID 10888872. 
  8. ^ Xin H, Yoon HG, Singh PB, Wong J, Qin J (Mar 2004). "Components of a pathway maintaining histone modification and heterochromatin protein 1 binding at the pericentric heterochromatin in Mammalian cells". J. Biol. Chem. 279 (10): 9539–46. doi:10.1074/jbc.M311587200. PMID 14665632. 
  9. ^ Liu Z, Fisher RA (Apr 2004). "RGS6 interacts with DMAP1 and DNMT1 and inhibits DMAP1 transcriptional repressor activity". J. Biol. Chem. 279 (14): 14120–8. doi:10.1074/jbc.M309547200. PMID 14734556. 

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