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Aliases DMP1, ARHP, ARHR, DMP-1, dentin matrix acidic phosphoprotein 1
External IDs MGI: 94910 HomoloGene: 68396 GeneCards: DMP1
Gene location (Human)
Chromosome 4 (human)
Chr. Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for DMP1
Genomic location for DMP1
Band 4q22.1 Start 87,650,307 bp[1]
End 87,664,361 bp[1]
RNA expression pattern
PBB GE DMP1 208175 s at fs.png

PBB GE DMP1 217067 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 4: 87.65 – 87.66 Mb Chr 4: 104.2 – 104.21 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Dentin matrix acidic phosphoprotein 1 is a protein that in humans is encoded by the DMP1 gene.[5][6][7]

Dentin matrix acidic phosphoprotein is an extracellular matrix protein and a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family (other members being DSPP, IBSP, MEPE, and SPP1). This protein, which is critical for proper mineralization of bone and dentin, is present in diverse cells of bone and tooth tissues. The protein contains a large number of acidic domains, multiple phosphorylation sites, a functional arg-gly-asp cell attachment sequence, and a DNA binding domain. In undifferentiated osteoblasts it is primarily a nuclear protein that regulates the expression of osteoblast-specific genes. During osteoblast maturation the protein becomes phosphorylated and is exported to the extracellular matrix, where it orchestrates mineralized matrix formation. Mutations in the gene are known to cause autosomal recessive hypophosphatemia, a disease that manifests as rickets and osteomalacia. The gene structure is conserved in mammals. Two transcript variants encoding different isoforms have been described for this gene.[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000152592 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029307 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Aplin HM, Hirst KL, Crosby AH, Dixon MJ (Mar 1996). "Mapping of the human dentin matrix acidic phosphoprotein gene (DMP1) to the dentinogenesis imperfecta type II critical region at chromosome 4q21". Genomics. 30 (2): 347–9. doi:10.1006/geno.1995.9867. PMID 8586437. 
  6. ^ Hirst KL, Simmons D, Feng J, Aplin H, Dixon MJ, MacDougall M (Jul 1997). "Elucidation of the sequence and the genomic organization of the human dentin matrix acidic phosphoprotein 1 (DMP1) gene: exclusion of the locus from a causative role in the pathogenesis of dentinogenesis imperfecta type II". Genomics. 42 (1): 38–45. doi:10.1006/geno.1997.4700. PMID 9177774. 
  7. ^ a b "Entrez Gene: DMP1 dentin matrix acidic phosphoprotein". 

Cell Cycle-Dependent Nuclear Localization of DMP1

J.O. MANCERA1, T. JHALA2, S. WANG2, C. QIN2, R. D'SOUZA2, and Y. LU2, 1School of Dentistry, Meharry Medical College, Nashville, TN, 2Department of Biomedical Sciences, Texas A&M Health Science Center, Baylor College of Dentistry, Dallas, TX

Further reading[edit]