DNA unwinding element

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A DNA unwinding element, frequently abbreviated to DUE and on occasion DNAUE, is the initiation site for the opening of the double helix structure of the DNA at the origin of replication for DNA synthesis.[1] It is A-T rich and denatures easily due to its low helical stability,[2] which allows the single-strand region to be recognized by Origin Recognition Complex.


  1. ^ Kowalski, D; Eddy, MJ (Dec 20, 1989). "The DNA unwinding element: a novel, cis-acting component that facilitates opening of the Escherichia coli replication origin.". The EMBO Journal. 8 (13): 4335–44. PMC 401646Freely accessible. PMID 2556269. 
  2. ^ Coman, D; Russu, IM (May 27, 2005). "Base pair opening in three DNA-unwinding elements.". The Journal of Biological Chemistry. 280 (21): 20216–21. doi:10.1074/jbc.M502773200. PMID 15784615.