DPP7

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DPP7
Protein DPP7 PDB 3JYH.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases DPP7, DPP2, DPPII, QPP, dipeptidyl peptidase 7
External IDs MGI: 1933213 HomoloGene: 22748 GeneCards: DPP7
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_013379

NM_031843

RefSeq (protein)

NP_037511

NP_114031.2
NP_114031

Location (UCSC) Chr 9: 137.11 – 137.12 Mb Chr 2: 25.35 – 25.36 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Dipeptidyl-peptidase 2 is an enzyme that in humans is encoded by the DPP7 gene.[3][4][5]

The protein encoded by this gene is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. The resting lymphocytes are maintained through suppression of apoptosis, a state which is disrupted by inhibition of this novel serine protease. The enzyme has strong sequence homology with prolylcarboxypeptidase and is active at both acidic and neutral pH.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Chiravuri M, Schmitz T, Yardley K, Underwood R, Dayal Y, Huber BT (Oct 1999). "A novel apoptotic pathway in quiescent lymphocytes identified by inhibition of a post-proline cleaving aminodipeptidase: a candidate target protease, quiescent cell proline dipeptidase". J Immunol. 163 (6): 3092–9. PMID 10477574. 
  4. ^ Fukasawa KM, Fukasawa K, Higaki K, Shiina N, Ohno M, Ito S, Otogoto J, Ota N (Jan 2001). "Cloning and functional expression of rat kidney dipeptidyl peptidase II". Biochem J. 353 (Pt 2): 283–90. doi:10.1042/0264-6021:3530283. PMC 1221570Freely accessible. PMID 11139392. 
  5. ^ a b "Entrez Gene: DPP7 dipeptidyl-peptidase 7". 

Further reading[edit]