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Deleted in lung and esophageal cancer 1

From Wikipedia, the free encyclopedia
DLEC1
Identifiers
AliasesDLEC1, CFAP81, DLC1, F56, DLC-1, deleted in lung and esophageal cancer 1, cilia and flagella associated protein, DLEC1 cilia and flagella associated protein, FAP81
External IDsOMIM: 604050; MGI: 2443671; HomoloGene: 84733; GeneCards: DLEC1; OMA:DLEC1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007335
NM_007336
NM_007337
NM_007338
NM_001321153

NM_177117
NM_001368820
NM_001368821

RefSeq (protein)

NP_001308082
NP_031361
NP_031363

n/a

Location (UCSC)Chr 3: 38.04 – 38.12 MbChr 9: 118.93 – 118.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Deleted in lung and esophageal cancer 1 is a protein that in humans is encoded by the DLEC1 gene. [5]

Function

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The cytogenetic location of this gene is 3p21.3, and it is located in a region that is commonly deleted in a variety of malignancies. Down-regulation of this gene has been observed in several human cancers including lung, esophageal, renal tumors, and head and neck squamous cell carcinoma. In some cases, reduced expression of this gene in tumor cells is a result of aberrant promoter methylation. Several alternatively spliced transcripts have been observed that contain disrupted coding regions and likely encode nonfunctional proteins.[provided by RefSeq, Mar 2016].

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000008226Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038060Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Deleted in lung and esophageal cancer 1". Retrieved 2018-04-05.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.