Dresch has been actively involved in the queercore scene since the 1980s, as the creator of the fanzine Chainsaw and contributor to several other seminal zines such as Outpunk and J.D.s, as well as contributing and being featured on the front cover of issue five of Deke Nihilson and Tom Jennings' zine Homocore. Additionally, she was a contributor to Tobi Vail's influential proto-Riot Grrrl fanzine, Jigsaw and Tammy Rae Carland's zine I (heart) Amy Carter. In 1992, she appeared in the cult film The Yo-Yo Gang, by G.B. Jones.
She founded the queercore independent record label Chainsaw Records in the early 1990s. Shortly after, she joined forces with Jody Bleyle and Kaia Wilson to form Team Dresch. Once drummer Marci Martinez was added to the line-up, the group began recording. The first single was released in 1994 on Kill Rock Stars. Their debut album in 1994, Personal Best and its follow-up, Captain My Captain, were released jointly by Chainsaw Records and Jody Bleyle's label Candy Ass Records. Team Dresch performs live and the members are interviewed in the documentary film She's Real, Worse Than Queer by Lucy Thane.
In 2004, she founded a new band, Davies vs. Dresch. In 2006, Team Dresch reunited and began touring again.
Dresch has appeared on many other artists' recordings, including Amy Ray's Prom; Third Sex's Card Carryin' (as producer, engineer and mixer); Phranc's Goofyfoot EP (bassist); Some Velvet Sidewalk's Shipwreck (guitarist and bassist); Hazel's Are You Going to Eat That? (producer); and Fifth Column's 36-C (guitarist). 
Dresch temporarily replaced Van Conner in the Screaming Trees and had a brief stint as bassist in Dinosaur Jr., accompanying them on their Australian tour in 1990. She collaborated with Slim Moon in the '80s Olympia-based garage band Nisqually Delta Podunk Nightmare, and played bass in the Olympia grunge/punk band Dangermouse. She has also worked with Rastro! (with Jen Smith), The Go Team, Mary Lou Lord, and Lois.
- McDonnell, Evelyn; Powers, Ann, editors: Rock She Wrote, Delta, N.Y.C., US, ISBN 0-385-31250-4 (1995)
- Darms, Lisa, editors: "Riot Grrrl Collection" ISBN 978-1-55861-822-0 (2015)
- Amy Ray – Guitar "Prom" LP
- Lois –Bass "Strumpet" LP
- Lois - Bass "Page Two" 7"
- Some Velvet Sidewalk - Bass "Shipwreck" LP
- Fifth Column – Guitar "36c" LP
- Dinosaur Jr. – Bass "The Wagon" 7"
- Phranc – Bass "Goofyfoot" 10"
- Mary Lou Lord – Guitar "Some Jingle Jangle Morning" 7"
- Raha, Maria (2005). "To The Enemies of Dyke Rock: Team Dresch". Cinderella's Big Score: Women Of The Punk And Indie Underground (1st ed.). Emeryville, CA: Seal Press. pp. 215–217. ISBN 978-1-58005-116-3.
- Marcus, Sara (2010). Girls to the Front: The True Story of the Riot Grrrl Revolution (1st ed.). New York: HarperPerennial. p. 349. ISBN 978-0-06-180636-0.
- Stovall, Natasha (March 1995). "Kicking Against the Pricks". Spin: 40.