EBF1

EBF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3LYR, 3MQI
Identifiers
Aliases	EBF1, COE1, EBF, O/E-1, OLF1, early B-cell factor 1, early B cell factor 1, EBF transcription factor 1
External IDs	OMIM: 164343; MGI: 95275; HomoloGene: 7297; GeneCards: EBF1; OMA:EBF1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	159,099,916 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	45,008,091 bp
RNA expression pattern
	Top expressed in
	synovial joint; ; synovial membrane; ; Achilles tendon; ; oocyte; ; buccal mucosa cell; ; skin of hip; ; cardiac muscle tissue of right atrium; ; parietal pleura; ; vena cava; ; spinal ganglia;
	Top expressed in
	external carotid artery; ; internal carotid artery; ; trigeminal ganglion; ; superior cervical ganglion; ; spinal ganglia; ; neural tube; ; ankle; ; lumbar spinal ganglion; ; subcutaneous adipose tissue; ; brown adipose tissue;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; protein binding; metal ion binding; DNA-binding transcription factor activity; protein dimerization activity; DNA-binding transcription factor activity, RNA polymerase II-specific; C2H2 zinc finger domain binding; DNA-binding transcription activator activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	multicellular organism development; regulation of transcription, DNA-templated; transcription, DNA-templated; regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	1879
	13591
	ENSG00000164330
	ENSMUSG00000057098
	Q9UH73
	Q07802
NM_001290360; NM_024007; NM_182708; NM_001324101; NM_001324103;
	NM_001324106; NM_001324107; NM_001324108; NM_001324109; NM_001324111; NM_001364155; NM_001364156; NM_001364157; NM_001364158; NM_001364159
	NM_001290709; NM_001290710; NM_001290711; NM_007897
NP_001277289; NP_001311030; NP_001311032; NP_001311035; NP_001311036;
	NP_001311037; NP_001311038; NP_001311040; NP_076870; NP_874367; NP_001351084; NP_001351085; NP_001351086; NP_001351087; NP_001351088
NP_001277638; NP_001277639; NP_001277640; NP_031923; NP_001349498;
	NP_001349500; NP_001349503; NP_001349504; NP_001349505; NP_001349506; NP_001349507; NP_001349508
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription factor COE1 is a protein that in humans is encoded by the EBF1 gene. EBF1 stands for Early B-Cell Factor 1.^[5]^[6]^[7]

Interactions

EBF1 has been shown to interact with ZNF423^[8] and CREB binding protein.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164330 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000057098 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=3126. {{cite web}}: Missing or empty |title= (help)
^ Milatovich A, Qiu RG, Grosschedl R, Francke U (Jul 1994). "Gene for a tissue-specific transcriptional activator (EBF or Olf-1), expressed in early B lymphocytes, adipocytes, and olfactory neurons, is located on human chromosome 5, band q34, and proximal mouse chromosome 11". Mamm. Genome. 5 (4): 211–5. doi:10.1007/BF00360547. PMID 8012110.
^ "Entrez Gene: EBF1 early B-cell factor 1".
^ Tsai RY, Reed RR (Jun 1997). "Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development". J. Neurosci. 17 (11): 4159–69. PMID 9151733.
^ Zhao F, McCarrick-Walmsley R, Akerblad P, Sigvardsson M, Kadesch T (Jun 2003). "Inhibition of p300/CBP by early B-cell factor". Mol. Cell. Biol. 23 (11): 3837–46. doi:10.1128/MCB.23.11.3837-3846.2003. PMC 155219. PMID 12748286.

Liberg D, Sigvardsson M, Akerblad P (2002). "The EBF/Olf/Collier family of transcription factors: regulators of differentiation in cells originating from all three embryonal germ layers". Mol. Cell. Biol. 22 (24): 8389–97. doi:10.1128/MCB.22.24.8389-8397.2002. PMC 139877. PMID 12446759.
Hagman J, Gutch MJ, Lin H, Grosschedl R (1995). "EBF contains a novel zinc coordination motif and multiple dimerization and transcriptional activation domains". EMBO J. 14 (12): 2907–16. PMC 398409. PMID 7796816.
Wang MM, Reed RR (1993). "Molecular cloning of the olfactory neuronal transcription factor Olf-1 by genetic selection in yeast". Nature. 364 (6433): 121–6. doi:10.1038/364121a0. PMID 8321284.
Hagman J, Belanger C, Travis A, Turck CW, Grosschedl R (1993). "Cloning and functional characterization of early B-cell factor, a regulator of lymphocyte-specific gene expression". Genes Dev. 7 (5): 760–73. doi:10.1101/gad.7.5.760. PMID 8491377.
Travis A, Hagman J, Hwang L, Grosschedl R (1993). "Purification of early-B-cell factor and characterization of its DNA-binding specificity". Mol. Cell. Biol. 13 (6): 3392–400. PMC 359803. PMID 8497258.
Tsai RY, Reed RR (1997). "Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development". J. Neurosci. 17 (11): 4159–69. PMID 9151733.
Gisler R, Jacobsen SE, Sigvardsson M (2000). "Cloning of human early B-cell factor and identification of target genes suggest a conserved role in B-cell development in man and mouse". Blood. 96 (4): 1457–64. PMID 10942392.
Gisler R, Sigvardsson M (2002). "The human V-preB promoter is a target for coordinated activation by early B cell factor and E47". J. Immunol. 168 (10): 5130–8. doi:10.4049/jimmunol.168.10.5130. PMID 11994467.
Smith EM, Gisler R, Sigvardsson M (2002). "Cloning and characterization of a promoter flanking the early B cell factor (EBF) gene indicates roles for E-proteins and autoregulation in the control of EBF expression". J. Immunol. 169 (1): 261–70. doi:10.4049/jimmunol.169.1.261. PMID 12077253.
Zhao F, McCarrick-Walmsley R, Akerblad P, Sigvardsson M, Kadesch T (2003). "Inhibition of p300/CBP by early B-cell factor". Mol. Cell. Biol. 23 (11): 3837–46. doi:10.1128/MCB.23.11.3837-3846.2003. PMC 155219. PMID 12748286.
Merluzzi S, Moretti M, Altamura S, Zwollo P, Sigvardsson M, Vitale G, Pucillo C (2004). "CD40 stimulation induces Pax5/BSAP and EBF activation through a APE/Ref-1-dependent redox mechanism". J. Biol. Chem. 279 (3): 1777–86. doi:10.1074/jbc.M305418200. PMID 14594818.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Bond HM, Mesuraca M, Carbone E, Bonelli P, Agosti V, Amodio N, De Rosa G, Di Nicola M, Gianni AM, Moore MA, Hata A, Grieco M, Morrone G, Venuta S (2004). "Early hematopoietic zinc finger protein (EHZF), the human homolog to mouse Evi3, is highly expressed in primitive human hematopoietic cells". Blood. 103 (6): 2062–70. doi:10.1182/blood-2003-07-2388. PMID 14630787.
Smith EM, Akerblad P, Kadesch T, Axelson H, Sigvardsson M (2005). "Inhibition of EBF function by active Notch signaling reveals a novel regulatory pathway in early B-cell development". Blood. 106 (6): 1995–2001. doi:10.1182/blood-2004-12-4744. PMID 15920012.
Akerblad P, Månsson R, Lagergren A, Westerlund S, Basta B, Lind U, Thelin A, Gisler R, Liberg D, Nelander S, Bamberg K, Sigvardsson M (2005). "Gene expression analysis suggests that EBF-1 and PPARgamma2 induce adipogenesis of NIH-3T3 cells with similar efficiency and kinetics". Physiol. Genomics. 23 (2): 206–16. doi:10.1152/physiolgenomics.00015.2005. PMID 16106032.
Martínez A, Mas A, de las Heras V, Arroyo R, Fernández-Arquero M, de la Concha EG, Urcelay E (2005). "Early B-cell Factor gene association with multiple sclerosis in the Spanish population". BMC Neurol. 5: 19. doi:10.1186/1471-2377-5-19. PMC 1291372. PMID 16255771.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Roessler S, Györy I, Imhof S, Spivakov M, Williams RR, Busslinger M, Fisher AG, Grosschedl R (2007). "Distinct promoters mediate the regulation of Ebf1 gene expression by interleukin-7 and Pax5". Mol. Cell. Biol. 27 (2): 579–94. doi:10.1128/MCB.01192-06. PMC 1800812. PMID 17101802.

External links

FactorBook EBF1

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164330 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000057098 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] ttp://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=3126. {{cite web}}: Missing or empty |title= (help)

[pmid8012110-6] Milatovich A, Qiu RG, Grosschedl R, Francke U (Jul 1994). "Gene for a tissue-specific transcriptional activator (EBF or Olf-1), expressed in early B lymphocytes, adipocytes, and olfactory neurons, is located on human chromosome 5, band q34, and proximal mouse chromosome 11". Mamm. Genome. 5 (4): 211–5. doi:10.1007/BF00360547. PMID 8012110.

[entrez-7] "Entrez Gene: EBF1 early B-cell factor 1".

[pmid9151733-8] Tsai RY, Reed RR (Jun 1997). "Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development". J. Neurosci. 17 (11): 4159–69. PMID 9151733.

[pmid12748286-9] Zhao F, McCarrick-Walmsley R, Akerblad P, Sigvardsson M, Kadesch T (Jun 2003). "Inhibition of p300/CBP by early B-cell factor". Mol. Cell. Biol. 23 (11): 3837–46. doi:10.1128/MCB.23.11.3837-3846.2003. PMC 155219. PMID 12748286.

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Interactions

References

Further reading

External links