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ERH (gene)

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ERH
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesERH, DROER, enhancer of rudimentary homolog (Drosophila), mRNA splicing and mitosis factor, ERH mRNA splicing and mitosis factor
External IDsOMIM: 601191; MGI: 108089; HomoloGene: 3274; GeneCards: ERH; OMA:ERH - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004450

NM_007951
NM_001347409

RefSeq (protein)

NP_004441

NP_001334338
NP_031977

Location (UCSC)Chr 14: 69.38 – 69.4 MbChr 12: 80.68 – 80.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Enhancer of rudimentary
crystal structure of enhancer of rudimentary homologue (erh)
Identifiers
SymbolER
PfamPF01133
InterProIPR000781
PROSITEPDOC00732
SCOP21j24 / SCOPe / SUPFAM
TCDB3.A.16
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

In molecular biology, Enhancer of rudimentary homolog is a protein that in humans is encoded by the ERH gene.[5][6][7]

The Drosophila protein enhancer of rudimentary protein is a small protein of 104 amino acids. It has been found to be an enhancer of the rudimentary gene, involved in pyrimidine biosynthesis.[8]

From an evolutionary point of view, enhancer of rudimentary is highly conserved and has been found to exist in probably all multicellular eukaryotic organisms.[6] It has been proposed that this protein plays a role in the cell cycle.


References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100632Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021131Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Isomura M, Okui K, Fujiwara T, Shin S, Nakamura Y (Sep 1996). "Cloning and mapping of a novel human cDNA homologous to DROER, the enhancer of the Drosophila melanogaster rudimentary gene". Genomics. 32 (1): 125–7. doi:10.1006/geno.1996.0086. PMID 8786099.
  6. ^ a b Gelsthorpe M, Pulumati M, McCallum C, Dang-Vu K, Tsubota SI (Apr 1997). "The putative cell cycle gene, enhancer of rudimentary, encodes a highly conserved protein found in plants and animals". Gene. 186 (2): 189–95. doi:10.1016/S0378-1119(96)00701-9. PMID 9074495.
  7. ^ "Entrez Gene: ERH enhancer of rudimentary homolog (Drosophila)".
  8. ^ Wojcik, E.; Murphy, A. M.; Fares, H.; Dang-Vu, K.; Tsubota, S. I. (1994). "Enhancer of rudimentaryp1, e(r)p1, a highly conserved enhancer of the rudimentary gene". Genetics. 138 (4): 1163–1170. doi:10.1093/genetics/138.4.1163. PMC 1206255. PMID 7896098.

Further reading

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[edit]
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Enhancer of rudimentary homolog (ERH)
  • PDBe-KB provides an overview of all the structure information available in the PDB for Mouse Enhancer of rudimentary homolog (ERH)


This article incorporates text from the public domain Pfam and InterPro: IPR000781