|Date of birth||22 April 1983|
|Place of birth||Kallithea, Greece|
|Height||1.91 m (6 ft 3 in)|
|2008||→ Eintracht Frankfurt (loan)||10||(1)|
|2010||→ Anorthosis (loan)||14||(9)|
|2010–2011||→ Marítimo (loan)||1||(0)|
|* Senior club appearances and goals counted for the domestic league only and correct as of 12 March 2017.
‡ National team caps and goals correct as of 19 January 2009
After establishing himself as one of the most talented young strikers in Greece during the first few years of his career at Panionios, Mantzios earned a transfer to Greek giants Panathinaikos in 2005.
In his first four seasons with Panathinaikos, Mantzios proved to be an important player, whether playing from the start or as a substitute – in total, scoring 18 goals in 68 Greek Super League matches and five goals in 20 European matches. One of his most notable achievements was scoring four goals in eight matches in the 2008–09 UEFA Champions League, helping Panathinaikos finish top of its group, ahead of Inter Milan, Werder Bremen and Anorthosis Famagusta FC.
In his last two seasons though, Mantzios struggled for playing time, with some tough new competition at the striker position, as Panathinaikos brought in prominent foreign strikers Djibril Cissé (Greek Super League top scorer in 2009–10 and 2010–11), Sebastián Leto and Sidney Govou, while generally employing a one-striker system. As a result, Panathinaikos sent Mantzios out on loan, to Anorthosis in 2009–10 (six goals in 14 games) and Portuguese club Marítimo in 2010–11 (only one match played, due to a knee injury).
Manztios' contract with Panathinaikos expired at the end of the 2010–11 season, and during the summer transfer period he joined Super League club OFI Crete on a one-year contract. In 2011–12, Manztios was OFI's leading scorer with seven goals in 22 Super League matches.
At the beginning of the season 2013-14, he signed for Levadiakos F.C. for a two-years' contact. On 18 August 2013, he made his debut with the club by scoring one goal in a 2-2 home draw against Panthrakikos.
After his two years spell in Levadiakos, who got relegated, he came close to agree on moving to Platanias, though the club attacked to Mantzios for not following the oral agreement they had and eventually the deal didn't close. After that event, Mantzios was approached by Veria. On 1 July 2015, the two sides made an oral agreement, and both sides will sign the contract in a due course.
After various rumours concerning the future of the player, Mantzios renewed his contract with Levadiakos for €300,000 till the summer of 2017.  He started the 2015-16 season by scoring the only goal in a 1-0 away win against Iraklis, following by two goals in the 2-1 home win against Asteras Tripoli. On 3 October 2015, he named man of the match giving the victory to his club in a 3-1 away win against Panthrakikos by scoring two goals and giving one assist. With these two goals he became the all-time top scorer of the club with 26 goals. On 18 October 2015, in the 7th day of the Greek Super League, with a penalty kick equalizing the score in a 2-2 home draw against Panetolikos. 
On 23 December 2015, his excellent performance in the first half of the 2015-16 season, attracts the interest of many clubs. Greek giants Olympiakos will probably make a move in January transfer window, as the experienced international will be an excellent replacement of Alan Pulido.  To complete this transfer, Olympiakos is willing to offer Levadiakos except from money the Comorian international forward El Fardou Ben Nabouhane, who arrived in Piraeus from Veria last summer but has not make a single appearance with the club yet.  On 17 February 2016, Mantzios' penalty kick allowed Levadiakos to salvage a 1-1 draw with Atromitos for the postponed 16th matchday of Greek Super League.  On 20 February 2016, Mantzios' penalty kick allowed Levadiakos to escape with a 1-0 home win against kalloni.  By scoring in that game Mantzios has achieved an excellent 11/11 record at penalties in Super League. The all-time record stands since season 1989-90, when Hungarian star of Olympiakos Lajos Detari extended its record to 14/14.  On 19 March 2016, he scored giving the lead to his club in a 2-2 away draw against Skoda Xanthi. On 17 April 2016, he scored in a glorious 3-0 home win against AEK Athens for the last day of the 2015-16 season. 
- "Evanggelos Mantzios". worldfootball.net.
- "ФК Баку подвергся новым санкциям на сумму более чем в 500.000$". http://www.azerifootball.com/ru/ (in Russian). Azeri Football. 10 May 2015. Retrieved 11 May 2015. External link in
- ΒΕΡΟΙΑ: Υπογράφει ο Λόπεθ έκλεισε άλλους τέσσερις
- Δικός του ο Μάντζιος! Retrieved 11 July 2015
- Μάντζιος ως το 2017 Retrieved 11 July 2015
- Φοβερή ανατροπή στην Κομοτηνή, 3-1 ο Λεβαδειακός Retrieved 3 October 2010
- Δεν ολοκλήρωσε την ανατροπή ο Λεβαδειακός, 2-2 με τον Παναιτωλικό Retrieved 18 October 2010
- Olympiakos monitoring Mantzios and Mygas Retrieved 23 December 2015
- Olympiakos to include Ben in Mantzios' transfer Retrieved 23 December 2015
- Levadeiakos hold off Atromitos to 1-1 draw Retrieved 17 February 2016
- Λεβαδειακός - Καλλονή 1-0 Retrieved 20 February 2016
- Mantzios' excellent penalty record Retrieved 22 February 2016
- SKODA Xanthi and Levadiakos draw after interesting match Retrieved 19 March 2016
- Λεβαδειακός - ΑΕΚ 3-0 Retrieved 17 April 2016