Exosome component 6

EXOSC6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2NN6
Identifiers
Aliases	EXOSC6, EAP4, MTR3, Mtr3p, hMtr3p, p11, Exosome component 6
External IDs	OMIM: 606490; MGI: 1919794; HomoloGene: 12469; GeneCards: EXOSC6; OMA:EXOSC6 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	70,251,940 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	111,784,296 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Brodmann area 23; ; postcentral gyrus; ; Brodmann area 46; ; superior frontal gyrus; ; middle temporal gyrus; ; Achilles tendon; ; entorhinal cortex; ; pons; ; external globus pallidus;
	Top expressed in
	embryo; ; morula; ; vasculature; ; temporal lobe; ; amygdala; ; spinal cord; ; brain stem; ; choroid plexus; ; meninges; ; bone marrow;
	More reference expression data
	n/a
Gene ontology
Molecular function	exoribonuclease activity; RNA binding;
Cellular component	cytoplasm; cytosol; exosome (RNase complex); nuclear exosome (RNase complex); cytoplasmic exosome (RNase complex); nucleolus; nucleus; nucleoplasm;
Biological process	regulation of mRNA stability; nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'; rRNA 3'-end processing; rRNA catabolic process; DNA deamination; nuclear mRNA surveillance; exonucleolytic catabolism of deadenylated mRNA; U4 snRNA 3'-end processing; polyadenylation-dependent snoRNA 3'-end processing; rRNA processing; positive regulation of isotype switching; isotype switching; RNA phosphodiester bond hydrolysis, exonucleolytic;
	Sources:Amigo / QuickGO
Orthologs
	118460
	72544
	ENSG00000223496
	ENSMUSG00000109941
	Q5RKV6
	Q8BTW3
	NM_058219
	NM_028274
	NP_478126
	NP_082550
	Wikidata
View/Edit Human	View/Edit Mouse

Exosome complex exonuclease MTR3 is an enzyme that in humans is encoded by the EXOSC6 gene.^[5]^[6]^[7]

Template:PBB Summary

Interactions

Exosome component 6 has been shown to interact with Exosome component 7,^[6]Exosome component 8^[6] and Exosome component 1.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000223496 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000109941 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chen CY, Gherzi R, Ong SE, Chan EL, Raijmakers R, Pruijn GJ, Stoecklin G, Moroni C, Mann M, Karin M (Nov 2001). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell. 107 (4): 451–64. doi:10.1016/S0092-8674(01)00578-5. PMID 11719186.
^ ^a ^b ^c ^d Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (Nov 2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring". J Mol Biol. 323 (4): 653–63. doi:10.1016/S0022-2836(02)00947-6. PMID 12419256.
^ "Entrez Gene: EXOSC6 exosome component 6".

Interactions

References

Further reading