FAU (gene)

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FAU
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases FAU, FAU1, Fub1, Fubi, MNSFbeta, RPS30, S30, asr1, Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed, ubiquitin like and ribosomal protein S30 fusion
External IDs MGI: 102547 HomoloGene: 37562 GeneCards: FAU
Gene location (Human)
Chromosome 11 (human)
Chr. Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for FAU
Genomic location for FAU
Band 11q13.1 Start 65,120,628 bp[1]
End 65,122,473 bp[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001997

NM_001160239
NM_001190436
NM_007990

RefSeq (protein)

NP_001988

NP_001153711
NP_001177365
NP_032016

Location (UCSC) Chr 11: 65.12 – 65.12 Mb Chr 11: 6.06 – 6.06 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

40S ribosomal protein S30 is a protein that in humans is encoded by the FAU gene.[5][6]

Function[edit]

This gene is the cellular homolog of the fox sequence in the Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV). It encodes a fusion protein consisting of the ubiquitin-like protein fubi at the N-terminus and ribosomal protein S30 at the C-terminus. It has been proposed that the fusion protein is post-translationally processed to generate free fubi and free ribosomal protein S30. Fubi is a member of the ubiquitin family, and ribosomal protein S30 belongs to the S30E family of ribosomal proteins. Whereas the function of fubi is currently unknown, ribosomal protein S30 is a component of the 40S subunit of the cytoplasmic ribosome. Pseudogenes derived from this gene are present in the genome. Similar to ribosomal protein S30, ribosomal proteins S27a and L40 are synthesized as fusion proteins with ubiquitin.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000149806 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038274 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Kas K, Schoenmakers E, van de Ven W, Weber G, Nordenskjold M, Michiels L, Merregaert J, Larsson C (Oct 1993). "Assignment of the human FAU gene to a subregion of chromosome 11q13". Genomics. 17 (2): 387–92. doi:10.1006/geno.1993.1337. PMID 8406491. 
  6. ^ a b "Entrez Gene: FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived); ribosomal protein S30". 

Further reading[edit]